Involvement of substance P in pial arteriolar vasodilatation during pneumococcal meningitis in the rat

Neuroreport
H W PfisterU Koedel

Abstract

The present study investigated whether the endogenous vasodilating neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) contribute to pial arteriolar vasodilatation in the early phase of pneumococcal meningitis in the rat. Using a closed cranial window preparation we measured the diameters of pial arterioles during 4 h after pneumococcal infection. Arteriolar vasodilatation in infected rats was significantly attenuated by pretreatment with the SP-antagonist spantide up to 3 h after infection. Neither post-treatment with spantide (administered 2 h after infection) nor pretreatment with the CGRP antagonist CGRP(8-37) affected the pneumococci-induced pial arteriolar dilatation. These data suggest that SP is involved as a mediator in early pneumococci-induced dilatation of pial arterioles.

Citations

Apr 13, 2001·Microscopy Research and Technique·O HoffmannJ R Weber
Sep 2, 1999·Infectious Disease Clinics of North America·U Koedel, H W Pfister
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J R WeberM A Moskowitz
Oct 6, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R PaulH W Pfister
Jun 1, 1996·Clinical and Experimental Pharmacology & Physiology·J E BrianD D Heistad
Jul 15, 2003·Clinical Microbiology Reviews·M van der FlierE I Tuomanen
Apr 8, 2014·Amino Acids·Miguel Muñoz, Rafael Coveñas
Aug 13, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Olaf HoffmannJoerg R Weber
Feb 22, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Olaf M HoffmannJoerg R Weber
Nov 30, 2006·Clinical Science·Jan P KonsmanAnne-Marie Van Dam
Jun 15, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Michael PedersenKirsten Møller
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.