Involvement of substance P, mast cells, TNF-alpha and ICAM-1 in the infiltration of inflammatory cells in human periapical granulomas

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
H KabashimaTadahiko Iijima

Abstract

Substance P (SP), a potent proinflammatory peptide present in sensory neurons, is believed to be a major mediator of neurogenic inflammation. The aim of this study was to examine the localization and involvement of SP, mast cells and tumor necrosis factor-alpha (TNF-alpha)-positive cells in human periapical granulomas. Sections from seven periapical granulomas were stained using a variety of immunohistochemical methods. SP-immunoreactive nerve fibers, mast cells and TNF-alpha-positive cells were found localized in the vicinity of blood vessels in all the samples of periapical granulomas. The vascular endothelial cells stained positively for E-selectin and intercellular adhesion molecule-1. SP, TNF-alpha-positive cells and E-selectin could not be detected in clinically healthy periodontal ligament, and served as a negative control. Our findings suggest that SP, mast cells, TNF-alpha-positive cells and E-selectin may modulate the pathogenesis of apical periodontitis and may be responsible for stimulating the formation of granuloma with the resorption of periapical bone.

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Citations

Dec 21, 2004·Journal of Molecular Histology·Maya V Gulubova, Tatyana I Vlaykova
Apr 5, 2012·Mediators of Inflammation·Paola Sacerdote, Luca Levrini
Mar 12, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Alessandra Cristina GomesSandra Helena Penha Oliveira
Oct 22, 2008·Journal of Endodontics·Asma A KhanKenneth M Hargreaves
Aug 14, 2012·Journal of Oral Rehabilitation·A AkcaliN Buduneli
Feb 28, 2014·Journal of Investigative and Clinical Dentistry·Erica Dorigatti de AvilaCinara Maria Camparis
Jan 28, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Tatiana Beber Teixeira-SalumAdriano Motta Loyola
Mar 6, 2008·Mediators of Inflammation·Sonja Pezelj-RibarićZoran Karlović
May 12, 2012·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·K A PatidarA P Patidar
Jan 28, 2014·Journal of Endodontics·Ildikó J Márton, Csongor Kiss
Apr 3, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·F.T. Lundy, G.J. Linden
Dec 24, 2004·Journal of Dental Research·T A SilvaF Q Cunha
Apr 27, 2004·Journal of Endodontics·Levent I TuncerBarbaros Oral
Sep 25, 2003·European Journal of Clinical Nutrition·M TamA Marcos
Oct 4, 2019·International Endodontic Journal·A De RossiS Y Fukada
Mar 26, 2005·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Aleksandra LukićRenata Petrović
Sep 7, 2019·Cancer Immunology Research·Stéphane TerrySalem Chouaib

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