Involvement of T cell Ig Mucin-3 (Tim-3) in the negative regulation of inflammatory bowel disease

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Xia LiGencheng Han

Abstract

Augmented intestinal T cells, especially CD4(+)T cells, are involved in the pathogenesis of inflammatory bowel disease (IBD). We used a murine 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model to investigate whether Tim-3, a negative regulator of CD4(+)T cells, is involved in the suppression of IBD. We found that blocking the Tim-3 signal pathway exacerbated TNBS-induced colitis, as shown by increased weight loss and aggravated tissue injury. Blockade of the Tim-3 pathway resulted in an increase in Tim-3(+)CD4T cells, a biased T effector cell response, and a decrease in Treg cells. It also resulted in an altered profile of co-stimulatory molecules expressed on lymphocytes, which partially explained the biased polarization of different T cell subsets. Our data suggest that the Tim-3 pathway is highly involved in the negative regulation of IBD. A better understanding of this pathway may shed new light on the pathogenesis of this disease.

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Citations

Nov 3, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Fengmin ShiGencheng Han
May 16, 2014·Immunologic Research·Jacob V Gorman, John D Colgan
Jul 26, 2011·Brain Research Bulletin·Zhi-Yuan ZhangZhiren Zhang
May 23, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Yoshihisa HiraishiSusumu Nakae
Oct 20, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachel E O'NeillXuefang Cao
Dec 7, 2018·Scandinavian Journal of Immunology·Ge LiGencheng Han
Nov 5, 2019·Nature Reviews. Immunology·Yochai WolfVijay K Kuchroo
Feb 1, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaomei YangGencheng Han
Dec 1, 2018·Mucosal Immunology·Maria E JoosseJanneke N Samsom
Jan 9, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhao-Hui TangZhiping Li
Mar 9, 2021·Expert Opinion on Therapeutic Targets·Yaoyao DuBing Wang

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