PMID: 7544195May 1, 1995Paper

Involvement of tachykinins in plasma extravasation induced by bradykinin and low pH medium in the guinea-pig conjunctiva

British Journal of Pharmacology
M FiginiP Geppetti

Abstract

1. The effect of bradykinin, capsaicin, substance P and low pH medium on plasma extravasation in the guinea-pig conjunctiva has been studied. Evans blue dye was measured in the conjunctiva after local instillation of the agents into the conjunctival sac. 2. Bradykinin (2-50 nmol), capsaicin (20-50 nmol) and substance P (0.5-5 nmol) caused a dose-dependent increase in plasma extravasation with the following order of potency: substance P > bradykinin = capsaicin. The effect of capsaicin (50 nmol) and substance P (5 nmol) was abolished by the tachykinin NK1 receptor antagonist, CP-99,994 (8 mumol kg-1, i.v.) (P < 0.01), whereas CP-100,263 (8 mumol kg-1, i.v.) the inactive enantiomer of CP-99,994 was without effect. CP-99,994 inhibited by 70% (P < 0.01) the effect of bradykinin. 3. The kinin B2 receptor antagonist, Hoe 140 (icatibant, 10 nmol kg-1, i.v.) abolished the response to bradykinin (50 nmol) (P < 0.01), but did not affect the responses to capsaicin (50 nmol) or substance P (5 nmol). Plasma extravasation induced by low pH medium (pH 1) was abolished by CP-99,994 (P < 0.01) and by Hoe 140 (P < 0.01). 4. The present findings suggest that: endogenous or exogenous tachykinins increase plasma extravasation in the guinea-pig conj...Continue Reading

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Mar 1, 1991·British Journal of Pharmacology·K WirthJ Knolle
May 1, 1968·British Journal of Pharmacology and Chemotherapy·N JancsóJ Szolcsányi
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·J J BowdenD M McDonald
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Citations

Feb 11, 1998·General Pharmacology·P Holzer
May 30, 2001·The International Journal of Biochemistry & Cell Biology·S Harrison, P Geppetti
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·F L RicciardoloP Geppetti
Apr 24, 2001·American Journal of Respiratory and Critical Care Medicine·S AmadesiP Geppetti
Jul 5, 2005·Expert Opinion on Investigational Drugs·P GeppettiC Bertrand
Jan 5, 2002·Expert Opinion on Investigational Drugs·G E BorodicE A Johnson
Aug 20, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Romina NassiniPierangelo Geppetti
Apr 10, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Madhav BhatiaJohn P Neoptolemos

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