Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy.

Journal of Ophthalmology
Masayoshi TakeuchiSho-Ichi Yamagishi

Abstract

Diabetic complications are a leading cause of acquired blindness, end-stage renal failure, and accelerated atherosclerosis, which are associated with the disabilities and high mortality rates seen in diabetic patients. Continuous hyperglycemia is involved in the pathogenesis of diabetic micro- and macrovascular complications via various metabolic pathways, and numerous hyperglycemia-induced metabolic and hemodynamic conditions exist, including increased generation of various types of advanced glycation end-products (AGEs). Recently, we demonstrated that glyceraldehyde-derived AGEs, the predominant structure of toxic AGEs (TAGE), play an important role in the pathogenesis of angiopathy in diabetic patients. Moreover, recent evidence suggests that the interaction of TAGE with the receptor for AGEs (RAGE) elicits oxidative stress generation in numerous types of cells, all of which may contribute to the pathological changes observed in diabetic complications. In this paper, we discuss the pathophysiological role of the TAGE-RAGE system in the development and progression of diabetic retinopathy.

References

Jan 1, 1992·Advances in Pharmacology·R Bucala, A Cerami
Jun 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J Hallfrisch
May 19, 1988·The New England Journal of Medicine·M BrownleeH Vlassara
Jul 1, 1985·The Journal of Cell Biology·I M Herman, P A D'Amore
Jan 1, 1995·Annual Review of Medicine·M Brownlee
Apr 1, 1994·Genitourinary Medicine·M Lyons
Nov 1, 1993·The American Journal of Clinical Nutrition·P A Mayes
Nov 1, 1993·Scientific American·J P Changeux
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y M LiH Vlassara
Apr 15, 1997·Annals of the New York Academy of Sciences·A W StittH Vlassara
Sep 4, 1998·Journal of the American Society of Nephrology : JASN·S SugiyamaK Kurokawa
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·K MiyamotoA P Adamis
Feb 10, 2000·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research GroupDavid M Nathan
Dec 8, 2000·Biochimica Et Biophysica Acta·A M SchmidtD M Stern
Dec 21, 2000·Current Atherosclerosis Reports·A M Schmidt, D Stern
Dec 21, 2000·Current Rheumatology Reports·J C Jennette, R J Falk
Feb 15, 2001·Archives of Internal Medicine·UNKNOWN DECODE Study Group, the European Diabetes Epidemiology Group.
Apr 24, 2001·Journal of the American Society of Nephrology : JASN·An S DE VrieseNorbert H Lameire
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Z WagnerJ Nagy
Jan 19, 2002·Biochemical and Biophysical Research Communications·Sho-ichi YamagishiZenji Makita
Jan 22, 2002·Journal of Clinical Laser Medicine & Surgery
Mar 2, 2002·Journal of Diabetes and Its Complications·Nobutaka OhgamiHitoshi Nakayama
Mar 22, 2002·Journal of Internal Medicine·H Vlassara, M R Palace
Aug 30, 2002·International Review of Neurobiology·Peter J Oates

❮ Previous
Next ❯

Citations

Sep 13, 2011·Amino Acids·Ross Milne, Seymour Brownstein
Aug 25, 2015·Progress in Retinal and Eye Research·Alan W StittNoemi Lois
Aug 4, 2015·Journal of Clinical Biochemistry and Nutrition·Mona S Ottum, Anahita M Mistry
Jun 21, 2017·Nutrients·Masayoshi TakeuchiMikihiro Tsutsumi
Sep 26, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·So Yeon KongW Robert Bruce
Mar 23, 2021·Biochemistry and Biophysics Reports·Tomoaki ShigetaTetsuro Yamamoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.