Involvement of tetrodoxin-sensitive sodium channels in rat growth hormone secretion induced by pituitary adenylate cyclase-activating polypeptide (PACAP)

Regulatory Peptides
Y MurakamiY Kato

Abstract

Both pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) and growth hormone-releasing hormone (GRH) stimulated growth hormone (GH) release from perfused rat anterior pituitary cells. Tetrodotoxin (TTX) blunted the GH release induced by PACAP-38 but not by GRH. Mefenamic acid, a blocker of non-selective cation channels, unaffected GH release elicited by PACAP-38 and GRH. These results suggest an involvement of TTX-sensitive Na+ channels but not Ca2+-activated nonselective cation channels in PACAP-38-induced GH secretion, and that post-receptor mechanisms for PACAP-38 are different from those activated by GRH.

References

Oct 16, 1989·Biochemical and Biophysical Research Communications·A MiyataD H Coy

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Citations

Jul 21, 2009·European Biophysics Journal : EBJ·Monika KrasowskaMustafa B A Djamgoz
Jul 24, 2010·Endocrine Reviews·Stanko S StojilkovicRichard Bertram
Feb 5, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Scott P FraserMustafa B A Djamgoz
Mar 18, 2006·The Journal of Physiology·William J Brackenbury, Mustafa B A Djamgoz
May 9, 2012·Journal of Neuroendocrinology·S S StojilkovicC A Stratakis
Mar 27, 2004·Experimental Biology and Medicine·Lloyd L AndersonColin G Scanes
Dec 2, 2009·The International Journal of Biochemistry & Cell Biology·Athina-Myrto ChioniMustafa B A Djamgoz

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