Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice

ELife
Damien LanfrayDenis Richard

Abstract

Acyl-CoA binding domain-containing 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA binding protein in which single nucleotide polymorphism has recently been associated with obesity in humans. In this report, we provide converging evidence indicating that a splice variant isoform of the Acbd7 mRNA is expressed and translated by some POMC and GABAergic-neurons in the hypothalamic arcuate nucleus (ARC). We have demonstrated that the ARC ACBD7 isoform was produced and processed into a bioactive peptide referred to as nonadecaneuropeptide (NDN) in response to catabolic signals. We have characterized NDN as a potent anorexigenic signal acting through an uncharacterized endozepine G protein-coupled receptor and subsequently via the melanocortin system. Our results suggest that ACBD7-producing neurons participate in the hypothalamic leptin signalling pathway. Taken together, these data suggest that ACBD7-producing neurons are involved in the hypothalamic control exerted on food intake and energy expenditure by the leptin-melanocortin pathway.

References

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Citations

Apr 3, 2019·The Journal of Clinical Investigation·Khalil BouyakdanThierry Alquier
May 28, 2017·Journal of Neural Transmission·Andrea Frozino RibeiroAngela Maria Ribeiro
Jul 13, 2019·Frontiers in Endocrinology·Serge H LuquetRiccarda Granata
Oct 22, 2016·Annals of the New York Academy of Sciences·Alexandre Caron, Denis Richard
Jul 12, 2017·Frontiers in Neuroscience·Damien Lanfray, Denis Richard
Oct 27, 2020·Glia·Bruno LebrunJean-Denis Troadec
Jul 10, 2019·Pharmacology & Therapeutics·Marie-Christine TononJérôme Leprince
Feb 12, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Markus IslingerMichael Schrader
Mar 13, 2021·Trends in Endocrinology and Metabolism : TEM·Léa MontégutGuido Kroemer

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Methods Mentioned

BETA
affinity purification
X-ray
protein assay
PCR
ELISA

Software Mentioned

GraphPad
DIALIGN
Prism
Vector NTI advance 11

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