Involvement of the adenylyl cyclase signaling system in the action of insulin and mollusk insulin-like peptide

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
M N PertsevaL Kuznetsova

Abstract

Involvement of the adenylyl cyclase signaling system in the mechanism of action of the mammalian insulin and epidermal growth factor as well as of insulin-like peptide isolated from the bivalve mollusk Anodonta cygnea has been studied. It was shown for the first time that insulin and insulin-like peptide exert in vitro the GTP-dependent stimulating action on the adenylyl cyclase activity. Epidermal growth factor has an analogous effect. Effectiveness of the peptides decreased in the order insulin-like peptide > epidermal growth factor > insulin in the foot smooth muscles of A. cygnea and insulin > epidermal growth factor > insulin-like peptide in the skeletal muscles of rat.

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Citations

Jan 14, 2003·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M N PertsevaL A Kuznetsova
Aug 2, 2008·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·A O Spakov, M N Pertseva
Nov 5, 2009·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·A O Shpakov
Jun 30, 2010·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·M N Pertseva, A O Shpakov
Jun 1, 2000·Obesity Research·A BellA Sorisky
Apr 1, 2009·The Journal of Physiology·Eduardo R RopelleCláudio T De Souza
Mar 20, 2010·The Journal of Medical Investigation : JMI·Hidekazu AraiEiji Takeda
Feb 29, 1996·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C SutherlandD K Granner
Sep 17, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·K Pazaitou-PanayiotouC S Mantzoros
Jul 9, 2017·Journal of Cellular Biochemistry·Mohammad Javad Saeedi BorujeniHamed Mirzaei
Jul 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S Chardin, R Romand

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