Involvement of the Androgen and Glucocorticoid Receptors in Bladder Cancer

International Journal of Endocrinology
Lucien McBethTerry D Hinds

Abstract

Bladder cancer is encountered worldwide having been associated with a host of environmental and lifestyle risk factors. The disease has a male to female prevalence of 3 : 1. This disparity has raised the possibility of the androgen receptor (AR) pathway being involved in the genesis of the disease; indeed, research has shown that AR is involved in and is likely a driver of bladder cancer. Similarly, an inflammatory response has been implicated as a major player in bladder carcinogenesis. Consistent with this concept, recent work on anti-inflammatory glucocorticoid signaling points to a pathway that may impact bladder cancer. The glucocorticoid receptor- (GR-) α isoform has an important role in suppressing inflammatory processes, which may be attenuated by AR in the development of bladder cancer. In addition, a GR isoform that is inhibitory to GRα, GRβ, is proinflammatory and has been shown to induce cancer growth. In this paper, we review the evidence of inflammatory mediators and the relationship of AR and GR isoforms as they relate to the propensity for bladder cancer.

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Citations

Jun 24, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Luana Samara Balduíno de SenaCassiano Francisco Weege Nonaka
Mar 30, 2017·PPAR Research·Melody ChiuTerry D Hinds
Dec 24, 2017·In Vitro Cellular & Developmental Biology. Animal·Yu-Hsiang Lee, Chien-Hsuan Yeh
Apr 4, 2021·International Journal of Molecular Sciences·Patricia Ramos-Ramírez, Omar Tliba
May 1, 2021·Biomolecules·Elizabeth Martínez-RojoJesica Escobar-Cabrera
Aug 10, 2021·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Zhichao MengKuimei Wang

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BETA
chemical castration

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