Involvement of the antimicrobial peptide LL-37 in human atherosclerosis

Arteriosclerosis, Thrombosis, and Vascular Biology
Kristina EdfeldtZhong-qun Yan

Abstract

Antimicrobial peptides are effector molecules of the innate immune system. To understand the function of vascular innate immunity in atherosclerosis, we investigated the role of LL-37, a cathelicidin antimicrobial peptide, in the disease process. Using real-time polymerase chain reaction, we found a 6-fold increase in human cationic antimicrobial protein 18/LL-37 transcript in human atherosclerotic lesions compared with normal arteries. Immunohistochemical analysis of atherosclerotic plaques showed that LL-37 was expressed mainly by macrophages and some endothelial cells. Western blot demonstrated existence of active LL-37 peptide and abundant proprotein in atheroma specimens. To understand the functional implication of LL-37 production in atherosclerosis, the transcription profile was assessed in endothelial cells treated with LL-37. Our data show that LL-37 induces expression of the adhesion molecule intercellular adhesion molecule-1 and the chemokine monocyte chemoattractant protein 1 in endothelial cells. Intriguingly, Chlamydia pneumoniae withstood the antimicrobial activity of LL-37 in vitro, although inflammatory response was induced on infection. LL-37 is produced in atherosclerotic lesions, where it may function as an ...Continue Reading

References

Sep 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M R EkmanP Saikku
Apr 1, 1993·The Journal of Infectious Diseases·C C KuoJ T Grayston
Jul 1, 1997·The Journal of Infectious Diseases·L A JacksonJ T Grayston
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·R BalsJ M Wilson
Sep 16, 1998·Antimicrobial Agents and Chemotherapy·J TurnerR I Lehrer
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·B AgerberthG H Gudmundsson
Jul 10, 2001·The Journal of Investigative Dermatology·R A DorschnerR L Gallo
Jan 25, 2002·Nature·Michael Zasloff
Mar 15, 2002·The Lancet Infectious Diseases·Maija Leinonen, Pekka Saikku
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Susanne Schaller-BalsRobert Bals
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monisha G ScottRobert E W Hancock
Oct 11, 2002·The New England Journal of Medicine·Peck Y OngDonald Y M Leung
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna Di NardoRichard L Gallo
Mar 11, 2003·Acta Oto-laryngologica·Seon Tae KimHeung-Man Lee
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Karen S MoultonJudah Folkman
Jun 5, 2003·The Journal of Clinical Investigation·Rembert KoczullaRobert Bals
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donald J DavidsonDavid P Speert
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Carrie M RosenbergerB Brett Finlay
Mar 24, 2004·Nature Reviews. Microbiology·Lee Ann Campbell, Cho-cho Kuo
Feb 25, 2005·Antimicrobial Agents and Chemotherapy·Manuela DonatiRoberto Cevenini
Jun 15, 2005·Cellular Microbiology·Peter BergmanBirgitta Agerberth

❮ Previous
Next ❯

Citations

Jan 12, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Mohamed Zaiou
Jun 7, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ylva Tranæus LindbladPeter Bárány
Feb 16, 2011·Nature Immunology·Göran K Hansson, Andreas Hermansson
Jan 13, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Adrian F GombartRavi Thadhani
Aug 13, 2010·Seminars in Dialysis·Ishir BhanRavi Thadhani
Apr 14, 2012·Circulation Research·Daniel I Simon, David Zidar
Nov 19, 2008·Molecular Medicine·Roland PálffyPeter Celec
Sep 21, 2013·Annual Review of Pathology·Tanya N MayadasClifford A Lowell
Feb 23, 2013·Cellular and Molecular Life Sciences : CMLS·Bart LegeinEsther Lutgens
Apr 8, 2015·Pharmaceuticals·Babatunji Emmanuel OyinloyeAbidemi Paul Kappo
Oct 25, 2014·Cardiovascular Research·Marcelo H PetriMagnus Bäck
May 18, 2016·British Journal of Biomedical Science·Irma Gonzalez-CurielBruno Rivas-Santiago
Jul 19, 2014·Atherosclerosis·Chandrakala Aluganti NarasimhuluSampath Parthasarathy
Feb 24, 2017·American Journal of Respiratory Cell and Molecular Biology·Jasmijn A SchrumpfPieter S Hiemstra
Oct 6, 2015·BioFactors·Katarzyna BandurskaPiotr Krupa
Jun 15, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·M Dolores SalvadoJesper Z Haeggström
Mar 20, 2012·Circulation Research·Oliver Soehnlein
Mar 8, 2012·Circulation Research·Yvonne DöringOliver Soehnlein
Sep 14, 2007·Immunological Reviews·Zhong-qun Yan, Göran K Hansson
Oct 26, 2007·International Journal of Cancer. Journal International Du Cancer·Seth B CoffeltAline B Scandurro
Nov 11, 2009·Journal of Cellular and Molecular Medicine·Oliver SoehnleinChristian Weber
Apr 1, 2015·Journal of Internal Medicine·M BäckE Lutgens
Apr 21, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Min WanJesper Z Haeggström
Feb 11, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Min WanJesper Z Haeggström
Apr 17, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Min WanJesper Z Haeggström
Nov 5, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·J Michelle Kahlenberg, Mariana J Kaplan
Sep 1, 2015·Journal of Cardiovascular Pharmacology·Colleen T Cole-JeffreyVinayak Shenoy
Nov 30, 2018·Frontiers in Pharmacology·John Pirault, Magnus Bäck
Dec 28, 2019·International Journal of Molecular Sciences·Suhanya V PrasadRobert Bucki
Jan 25, 2018·Anais Brasileiros De Dermatologia·Asli Akin BelliIbrahim Altun
Mar 30, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Sara DahlBengt-Olof Nilsson

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