Involvement of the basolateral amygdala in muscarinic cholinergic modulation of extinction memory consolidation.

Neurobiology of Learning and Memory
Mariano M BocciaJ L McGaugh

Abstract

Previous studies have reported that drugs affecting neuromodulatory systems within the basolateral amygdala (BLA), including drugs affecting muscarinic cholinergic receptors, modulate the consolidation of many kinds of training, including contextual fear conditioning (CFC). The present experiments investigated the involvement of muscarinic cholinergic influences within the BLA in modulating the consolidation of CFC extinction memory. Male Sprague Dawley rats implanted with unilateral cannula aimed at the BLA were trained on a CFC task, using footshock stimulation, and 24 and 48 h later were given extinction training by replacing them in the apparatus without footshock. Following each extinction session they received intra-BLA infusions of the cholinergic agonist oxotremorine (10 ng). Immediate post-extinction BLA infusions significantly enhanced extinction but infusions administered 180 min after extinction training did not influence extinction. Thus the oxotremorine effects were time-dependent and not attributable to non-specific effects on retention performance. These findings provide evidence that, as previously found with original CFC learning, cholinergic activation within the BLA modulates the consolidation of CFC extinct...Continue Reading

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Citations

Aug 16, 2008·Psychopharmacology·James L McGaugh, Benno Roozendaal
Apr 19, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Edwin SantiniJames T Porter
Sep 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Edwin Santini, James T Porter
Feb 27, 2014·Neurobiology of Learning and Memory·Elisabetta Baldi, Corrado Bucherelli
Feb 5, 2014·Pharmacology, Biochemistry, and Behavior·Nicole L T MooreRaymond F Genovese
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Cristiane FuriniIvan Izquierdo
Apr 25, 2012·Behavioural Brain Research·Natalia Gindri FiorenzaJociane C Myskiw
Feb 15, 2011·Behavioural Brain Research·Lianne RobinsonGernot Riedel
Jan 25, 2011·Pharmacology, Biochemistry, and Behavior·Gary B Kaplan, Katherine A Moore
Jun 28, 2015·Behavioural Brain Research·Juan Facundo MoriciNoelia V Weisstaub
Apr 19, 2015·Neuroscience and Biobehavioral Reviews·Elisabetta Baldi, Corrado Bucherelli
Jan 7, 2015·Annual Review of Psychology·James L McGaugh
Jun 7, 2016·Neurobiology of Learning and Memory·Dayan Knox
Sep 6, 2020·Annals of Clinical and Translational Neurology·Weimin ZhengZhiqun Wang
Oct 6, 2016·Journal of Neuroscience Research·Marlene A Wilson, Jim R Fadel
Dec 12, 2020·Neurobiology of Learning and Memory·M C KrawczykM M Boccia

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