Involvement of the Bombyx Scr gene in development of the embryonic silk gland

Developmental Biology
H KokuboY Suzuki

Abstract

Homeotic selector genes determine the identity of each segment and induce the differentiation of segment-specific organs. To analyze how the silk glands of the lepidopteran, Bombyx mori, develop, we cloned and identified two genes that encode the homeodomain and its flanking regions identical to the corresponding regions of Deformed and Sex combs reduced. Using in situ hybridization and immunohistochemistry, we analyzed the expression patterns of these genes during Bombyx embryogenesis. Bombyx Deformed is expressed in the mandibular and maxillary segments, whereas expression of Bombyx Sex combs reduced is first limited to the labial segment and at later stages extended to the anterior part of the prothoracic segment. The expression of Bombyx Sex combs reduced then disappears from the invaginating placodes of silk glands where expression of Bombyx fork head/SGF-1 follows. In the Nc/Nc mutant embryos, which lack the 3' end region of Bombyx Antennapedia, in addition to the expression in the labial segment, the Bombyx Sex combs reduced is expressed ectopically in the thoracic and abdominal regions, and Bombyx fork head/SGF-1 is also ectopically expressed in the T1, T2, and T3 segments, resulting the ectopic induction of the silk gl...Continue Reading

References

Mar 1, 1987·American Heart Journal·K Ausubel, B Gitler
Apr 21, 1995·The Journal of Biological Chemistry·V MachY Suzuki
Jun 1, 1996·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T NagataM Fukuta
Jun 1, 1996·Development Genes and Evolution·H KokuboY Suzuki
Oct 1, 1988·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Gerd Jürgens, Detlef Weigel
Aug 1, 1994·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Kazuhito AmanaiTetsuya Ohtaki

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Citations

Sep 16, 2003·Gene Expression Patterns : GEP·S Dhawan, K P Gopinathan
Nov 2, 2012·EvoDevo·Joshua F Coulcher, Maximilian J Telford
Mar 19, 2013·EvoDevo·Chilinh NguyenMolly Duman-Scheel
Dec 21, 2002·Evolution & Development·Cynthia L Hughes, Thomas C Kaufman
Nov 6, 2015·International Journal of Molecular Sciences·Meng MengDaojun Cheng
Jan 26, 2018·Archives of Insect Biochemistry and Physiology·Ze-Wei RenDun Wang
May 16, 2001·Genesis : the Journal of Genetics and Development·C D CurtisR E Denell
Mar 21, 2021·Insect Biochemistry and Molecular Biology·Sihan HouChun Liu
Aug 24, 2021·Frontiers in Cell and Developmental Biology·James C-G HombríaCarlos Sánchez-Higueras

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