Involvement of the bone morphogenetic protein/receptor system during follicle development in the bovine ovary: Hormonal regulation of the expression of bone morphogenetic protein 7 (BMP-7) and its receptors (ActRII and ALK-2)

Molecular and Cellular Endocrinology
Takashi ShimizuAkio Miyamoto

Abstract

Bone morphogenetic proteins (BMPs) are crucial factors in follicular growth and development. Among the BMP ligands, BMP-7 which use ActRII as their type II receptor, strongly bind to ALK-2 as their type I receptor. However, whether their receptors are expressed and the regulatory mechanisms controlling their expression during the process of bovine follicle development are still unknown. The aim of the present study was to clarify the involvement of the receptor system for BMP-7 in follicular selection by examining the effects of follicle-stimulating hormone (FSH) and estradiol (E2) on the regulation of ActRII and ALK-2 mRNA expression in bovine granulosa cells (GCs). To observe mRNA expression, follicles were obtained from heifers and GCs were classified into two groups: pre-selection follicles (PRF; follicles with an average diameter of 7 mm and low E2) and post-selection follicles (POF; follicles with an average diameter of 15 mm and high E2). The theca cell (TC) layer and GCs were harvested from aspirated follicles. For in vitro studies, GCs were obtained from bovine follicles of 4-7 mm diameter and cultured in Dulbecco's modified Eagle's/F12 (DMEM/F-12) medium with 10% fetal calf serum for 24h. The medium was then replaced ...Continue Reading

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Citations

Nov 13, 2010·Molecular and Cellular Biochemistry·Hiromichi YamashitaTakashi Shimizu
Nov 8, 2011·Bioscience, Biotechnology, and Biochemistry·Hyun-Ju IhnKwang Dong Kim
Jun 3, 2014·Reproductive Biology and Endocrinology : RB&E·Juliano C da SilveiraGerrit J Bouma
Feb 22, 2008·Molecular Reproduction and Development·Michael K SkinnerEric E Nilsson
Jul 26, 2013·Biology of Reproduction·Yuji HiraoNaoki Takenouchi
Sep 18, 2009·Clinical Orthopaedics and Related Research·Norine AlamReggie C Hamdy
Apr 11, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Francois ParadisGeorge R Foxcroft
Oct 21, 2020·Molecular Biology Reports·Michail PargianasTheologos M Michaelidis

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