Involvement of the brain histaminergic system in addiction and addiction-related behaviors: a comprehensive review with emphasis on the potential therapeutic use of histaminergic compounds in drug dependence

Progress in Neurobiology
Christian BrabantEzio Tirelli

Abstract

Neurons that produce histamine are exclusively located in the tuberomamillary nucleus of the posterior hypothalamus and send widespread projections to almost all brain areas. Neuronal histamine is involved in many physiological and behavioral functions such as arousal, feeding behavior and learning. Although conflicting data have been published, several studies have also demonstrated a role of histamine in the psychomotor and rewarding effects of addictive drugs. Pharmacological and brain lesion experiments initially led to the proposition that the histaminergic system exerts an inhibitory influence on drug reward processes, opposed to that of the dopaminergic system. The purpose of this review is to summarize the relevant literature on this topic and to discuss whether the inhibitory function of histamine on drug reward is supported by current evidence from published results. Research conducted during the past decade demonstrated that the ability of many antihistaminic drugs to potentiate addiction-related behaviors essentially results from non-specific effects and does not constitute a valid argument in support of an inhibitory function of histamine on reward processes. The reviewed findings also indicate that histamine can e...Continue Reading

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Citations

Jun 10, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Saara NuutinenPertti Panula
Oct 24, 2012·Behavioural Brain Research·Vincent DidoneEtienne Quertemont
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Oct 30, 2016·European Journal of Pharmacology·Christian BrabantEzio Tirelli
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Oct 17, 2020·Journal of Psychopharmacology·Iñigo Pallardo-FernándezLuis F Alguacil
Feb 17, 2019·European Journal of Pharmacology·Benjamin HuytsEzio Tirelli
Jan 26, 2021·Behavioural Pharmacology·Vanessa MinerviniCharles P France

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