Involvement of the CACNA1A gene containing region on 19p13 in migraine with and without aura

Neurology
G M TerwindtDutch Migraine Genetics Research Group

Abstract

To assess the involvement of the 19p13 familial hemiplegic migraine (FHM) locus in migraine with and without aura. Migraine with and without aura are likely to be polygenetic multifactorial disorders. FHM is a rare dominantly inherited type of migraine with aura. In about 50% of families, FHM is caused by mutations in the P/Q-type calcium channel alpha(1A)-subunit (CACNA1A) gene on chromosome 19p13. The CACNA1A gene is thus a good candidate gene for "nonhemiplegic" migraine with or without aura. The authors performed an affected sibpair analysis using flanking and CACNA1A intragenic markers. The authors assessed the occurrence of shared parental marker alleles among 189 affected siblings from 36 extended families with typical migraine with or without aura. Sibling pairs with any form of migraine had inherited the same 19p13 CACNA1A-containing region significantly more frequently than expected by chance (maximum multipoint lod score = 1.22). This result was almost exclusively dependent on the increased sharing found in sibling pairs with migraine with aura (maximum multipoint lod score = 1.41). The locus-specific relative risk for a sibling (lambda(s)) to suffer from migraine with aura, defined as the increase in risk of the tra...Continue Reading

Citations

Sep 28, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Mari A KaunistoMaija Wessman
Aug 18, 2006·Der Nervenarzt·T Freilinger, M Dichgans
Jul 16, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Suneet MehrotraAntoinette MaassenVanDenBrink
Apr 27, 2011·Molecular Genetics and Genomics : MGG·Bridget H Maher, Lyn R Griffiths
Aug 25, 2004·Current Neurology and Neuroscience Reports·Shilpi Pradhan, Sophia M Chung
Aug 30, 2003·Current Pain and Headache Reports·T Bartsch, Peter J Goadsby
May 2, 2003·Current Pain and Headache Reports·Esther KorsMichel Ferrari
May 24, 2005·Current Pain and Headache Reports·J HaanM D Ferrari
Dec 26, 2001·Brain Research. Brain Research Reviews·A Gorji
Jul 10, 2003·Lancet Neurology·Anne DucrosMarie-Germaine Bousser
Feb 15, 2002·Cephalalgia : an International Journal of Headache·C SjöstrandJ Hillert
May 8, 2002·Cephalalgia : an International Journal of Headache·E ThomasJ Schoenen
May 8, 2002·Cephalalgia : an International Journal of Headache·P Barbanti, G Fabbrini
Sep 17, 2002·Cephalalgia : an International Journal of Headache·J HaanM D Ferrari
Feb 27, 2003·Cephalalgia : an International Journal of Headache·A AmbrosiniJ Schoenen
Feb 27, 2003·Cephalalgia : an International Journal of Headache·A M J M van den Maagdenberg, J J Plomp
Apr 18, 2003·Cephalalgia : an International Journal of Headache·A Proietti CecchiniG Nappi
Jun 6, 2002·Headache·Peter S SándorJean Schoenen
Jan 25, 2002·The New England Journal of Medicine·Peter J GoadsbyMichel D Ferrari
Jan 18, 2002·Current Opinion in Neurology·Robert W Baloh
Mar 20, 2004·Cephalalgia : an International Journal of Headache·A EbersbergerF Richter
Dec 21, 2004·Cephalalgia : an International Journal of Headache·W B Young, T D Rozen
Mar 19, 2005·Cephalalgia : an International Journal of Headache·A GozalovJ Olesen
Sep 16, 2005·Cephalalgia : an International Journal of Headache·I DomitrzH Kwieciñski
Aug 24, 2007·Cephalalgia : an International Journal of Headache·A GozalovJ Olesen
Nov 1, 2007·Cephalalgia : an International Journal of Headache·D MagisUNKNOWN EUROHEAD Project
May 21, 2009·Human Genetics·Boukje de VriesArn M J M van den Maagdenberg
May 13, 2003·Clinical Cornerstone·N T Mathew
Jan 23, 2002·American Journal of Medical Genetics·R A LeaL R Griffiths
Jun 5, 2002·Current Opinion in Neurology·Esther E KorsMichel D Ferrari
Sep 2, 2008·Expert Review of Neurotherapeutics·Pasquale Montagna
Feb 6, 2008·The Journal of Headache and Pain·Anna AmbrosiniJean Schoenen
Mar 18, 2008·The Journal of Headache and Pain·Pasquale Montagna
Dec 7, 2007·The Journal of Headache and Pain·Maria PianePaolo Martelletti
Mar 22, 2007·Computers in Biology and Medicine·U BaysalM Demirci
Oct 31, 2006·Pharmacology & Therapeutics·Saurabh GuptaAntoinette MaassenVanDenBrink
Mar 2, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Malene KirchmannJes Olesen
Mar 26, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Lannie LigthartDorret I Boomsma
Dec 11, 2002·American Journal of Human Genetics·D SoragnaM L Mostacciuolo
Nov 18, 2004·Journal of the Neurological Sciences·R CurtainL R Griffiths
May 4, 2004·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Daniel Martín Fernández-MayoralasJaime Campos-Castelló
Aug 16, 2005·Vascular Pharmacology·D K ArulmozhiS L Bodhankar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.