Abstract
The basic helix-loop-helix (bHLH) transcriptional factor E2A has previously been shown to play a critical role in early B cell development, with E2A knockout mice and Id1 transgenic mice showing an arrest at the pro-B cell stage of development. More recent data suggest that E2A, through an interaction with the immunoglobulin heavy chain 3' enhancer, might also regulate later events in B cell development such as heavy chain class switching. The patterns of E2A protein expression in secondary lymphoid tissues support a role in later stages of B cell maturation. In particular, immunostaining reveals upregulation of E2A protein in cells of the dark zone of the germinal center, the site of immunoglobulin heavy chain class switching. To examine the role of E2A in class switching, the inhibitory HLH protein Id1 was expressed in B cell lines which normally undergo spontaneous and inducible switching from IgM to IgA. The forced expression of Id1 in these cell lines effectively blocked class switching. This Id1 blockade of class switching did not occur via downregulation of immunoglobulin heavy chain germline transcription or through inhibition of cell cycling. Furthermore, Id1 inhibited spontaneous and, to a lesser degree, cytokine indu...Continue Reading
References
Apr 1, 1992·Immunological Reviews·C Berek
Aug 1, 1991·Genes & Development·M SchlisselD Baltimore
Jan 1, 1991·International Immunology·A C WhitmoreL W Arnold
Jan 26, 1990·Science·P HenthornT Kadesch
Apr 6, 1990·Cell·R BenezraH Weintraub
Mar 11, 1985·Nucleic Acids Research·P FortJ M Blanchard
Apr 1, 1994·The Journal of Experimental Medicine·Y WakatsukiW Strober
Jun 1, 1995·European Journal of Immunology·K B MeyerS Pettersson
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G A Daniels, M R Lieber
Jan 27, 1995·Cell·W C ShaD Baltimore
Jun 1, 1994·Genes & Development·A IavaroneM A Israel
Dec 2, 1994·Cell·Y ZhuangH Weintraub
Dec 2, 1994·Cell·G BainM van Roon
Dec 16, 1994·Cell·R Benezra
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·A F Voronova, F Lee
Sep 1, 1994·Molecular and Cellular Biology·T GenettaT Kadesch
Mar 11, 1994·Nucleic Acids Research·V RiechmannF Sablitzky
Jun 3, 1994·Cell·M CognéF W Alt
Jul 1, 1993·The Journal of Experimental Medicine·Y Wakatsuki, W Strober
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·V J RobertsC Murre
Citations
Dec 31, 2003·Gene·Kikumi Hata, Junichiro Mizuguchi
May 29, 1998·Current Opinion in Immunology·T Reya, R Grosschedl
Oct 22, 2005·Nature Immunology·Cornelis Murre
Nov 7, 2006·Nature Immunology·Michael A CannarileAnanda W Goldrath
Mar 10, 2001·Cold Spring Harbor Symposia on Quantitative Biology·C Murre
Dec 28, 1999·Molecular and Cellular Biology·M E Massari, C Murre
Sep 21, 2002·Molecular and Cellular Biology·Sujatha NagulapalliMichael L Atchison
Feb 28, 2002·Annual Review of Immunology·Tasuku HonjoMasamichi Muramatsu
Feb 28, 2002·Annual Review of Immunology·Melanie W QuongCornelis Murre
Jun 9, 2009·BMC Cancer·Jason P W CareyJaideep Chaudhary
Nov 14, 1997·The Journal of Experimental Medicine·F C Kuo, J Sklar
Sep 8, 2011·European Journal of Immunology·Kanutte HuseJune H Myklebust
Jan 19, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·K Zhang, H K Cheah
Feb 13, 2001·Mechanisms of Development·S H HsuH Li
Aug 13, 1999·Molecular Cell·M E MassariC Murre
Apr 22, 2014·Parasitology International·Jyoti JoshiSukhbir Kaur
Apr 21, 2012·Blood·Elena CubedoIzidore S Lossos
Apr 30, 2003·Nature Immunology·Camil Elie SayeghCornelis Murre
Feb 13, 2002·Oncogene·R Rivera, C Murre
Jan 8, 2011·Leukemia·I Saborit-VillarroyaS Deaglio
Feb 5, 2003·The Journal of Biological Chemistry·Mathieu TremblayTrang Hoang
Sep 29, 2006·Journal of Medical Microbiology·Hatice OzbilgeSuleyman Yazar
Aug 24, 1999·Molecular and Cellular Biology·L PanY Zhuang
Jun 20, 1998·Molecular and Cellular Biology·M E MassariC Murre
Oct 19, 2001·Oncogene·S E AsplandC Murre
Jun 3, 2021·Cell Reports·Lin SunChen Dong
Jul 17, 1998·The American Journal of Pathology·M N Rutherford, D P LeBrun