Involvement of the fibrogenic cytokines, TGF-beta and bFGF, in the pathogenesis of idiopathic myelofibrosis

Pathologie-biologie
M C Le Bousse-KerdilèsFrench INSERM research network on Idiopathic Myelofibrosis

Abstract

Idiopathic Myelofibrosis (IMF), is a chronic myeloproliferative disorder characterized by the association of myeloproliferation and myelofibrosis. The pathophysiological mechanisms resulting in this disease remain still unclear. The myeloproliferation appeared to result from the clonal amplification of hematopoietic progenitors. In contrast, fibroblasts participating in myelofibrosis were shown to be polyclonal, thus suggesting that myelofibrosis was a reactive process. We studied the role of two growth factors TGF-beta and bFGF, which display potent fibrogenic properties and are major regulators of primitive hematopoiesis, in IMF pathogenesis. We demonstrated an increase of TGF-beta and bFGF expression in circulating megakaryocytic cells and platelets, together with alterations of the expression of these cytokines and their receptors in hematopoietic CD34+ progenitor cells from IMF patients. Our results suggested that TGF-beta and bFGF are involved both in myelofibrosis and myeloproliferation which characterize IMF.

References

Jan 1, 1990·Annual Review of Cell Biology·J Massagué
Jan 1, 1989·Progress in Growth Factor Research·M Klagsbrun
Jul 1, 1983·British Journal of Haematology·D DouerM J Cline
Sep 1, 1994·British Journal of Haematology·J T Reilly
Sep 1, 1994·British Journal of Haematology·M C MartyréF Bauters
Aug 4, 1994·Nature·J L WranaJ Massagué
May 1, 1996·Leukemia & Lymphoma·F Smadja-JoffeJ P Levesque

❮ Previous
Next ❯

Citations

Aug 2, 2008·Blood·Jean-Jacques LatailladeUNKNOWN French INSERM and the European EUMNET Networks on Myelofibrosis
Mar 9, 2012·Therapeutics and Clinical Risk Management·Alen OstojicSrdan Verstovsek
Jul 21, 2005·British Journal of Haematology·Claire N Harrison
May 7, 2004·European Journal of Haematology·K PanteliK Bourantas
Nov 7, 2015·Mediators of Inflammation·Gregor HoermannPeter Valent
Apr 12, 2003·Leukemia & Lymphoma·Eisuke UeharaMasami Nagai
Aug 3, 2002·Leukemia & Lymphoma·Alain SchmittElisabeth M Cramer
Dec 29, 2004·Leukemia & Lymphoma·Brijesh AroraAyalew Tefferi
Nov 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ayalew Tefferi
Feb 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ayalew TefferiAnimesh Pardanani
May 14, 2005·Journal of Pediatric Hematology/oncology·Mandeep WaliaMonika Sharma
Mar 3, 2004·The Journal of Clinical Investigation·Medhat ShehataHeinz Gisslinger
Nov 27, 2004·Cancer·Bryan T HennessySrdan Verstovsek
Apr 14, 2017·JCI Insight·Lanzhu YuePearlie K Epling-Burnette
Sep 5, 2008·Leukemia·J KotaS N Constantinescu
Jan 11, 2008·Leukemia·N Kröger, R A Mesa
Aug 31, 2007·European Journal of Haematology. Supplementum·Francisco Cervantes
Dec 13, 2007·Acta Haematologica·Dorit Almoznino-SarafianNatan Cohen
Mar 21, 2020·British Journal of Haematology·Naseema Gangat, Ayalew Tefferi
Apr 5, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John Mascarenhas, Ronald Hoffman
Mar 2, 2021·Hematology/oncology Clinics of North America·Sangeetha Venugopal, John Mascarenhas
Jun 20, 2006·Best Practice & Research. Clinical Haematology·Hedia ChagraouiWilliam Vainchenker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.