Involvement of the FOXO6 transcriptional factor in breast carcinogenesis

Oncotarget
François LallemandSandrine M Caputo

Abstract

In mammals, FOXO transcriptional factors form a family of four members (FOXO1, 3, 4, and 6) involved in the modulation proliferation, apoptosis, and carcinogenesis. The role of the FOXO family in breast cancer remains poorly elucidated. According to the cellular context and the stage of the disease, FOXOs can have opposite effects on carcinogenesis. To study the role of FOXOs in breast carcinogenesis in more detail, we examined their expression in normal tissues, breast cell lines, and a large series of breast tumours of human origin. We found a very low physiological level ofFOXO6expression in normal adult tissues and high levels of expression in foetal brain.FOXOgene expressions fluctuate specifically in breast cancer cells compared to normal cells, suggesting that these genes may have different roles in breast carcinogenesis. For the first time, we have shown that, among the variousFOXOgenes, onlyFOXO6was frequently highly overexpressed in breast cell lines and tumours. We also found that inhibition of the endogenous expression of FOXO6 by a specific siRNA inhibited the growth of the human breast cell lines MDA-MB-468 and HCC-38. FACS and Western blot analysis showed that inhibition of endogenous expression of FOXO6 induced ...Continue Reading

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Citations

Oct 16, 2018·Journal of Cellular Biochemistry·Quanying LiChangjiang Qin
Jul 10, 2020·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Yousif A KaririEmad A Rakha

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Methods Mentioned

BETA
transfection
FACS
protein assay
electrophoresis
PCR

Software Mentioned

PE Biosystems
Oligo

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