Involvement of the human ventrolateral thalamus in olfaction

Journal of Neurology
S ZobelM Kronenbuerger

Abstract

It is widely assumed that the thalamus is not involved in olfaction. The ventrolateral thalamus is, however, closely connected to the contralateral cerebellum, which is involved in the sense of smell based on findings from functional imaging studies and findings of olfactory deficits in patients with cerebellar disease. We hypothesized that olfactory deficits following lesions of the ventrolateral thalamus may be similar to olfactory deficits following cerebellar lesions. Fifteen patients with a focal thalamic lesion involving the ventrolateral thalamus were examined and compared to 15 patients with a focal cerebellar lesion and 15 healthy controls. A detailed olfactory test ("Sniffin' Sticks") was used to assess different olfactory functions separately for each nostril. In the group of patients with a lesion of the ventrolateral thalamus, an impairment of the odor threshold was found at the ipsilateral nostril, consistent with the unilateral orientation of the olfactory system in the telencephalon. In the group of patients with a cerebellar lesion, an olfactory deficit at the contralesional nostril emerged. In controls, no significant side difference was found. The involvement of the ventrolateral thalamus in olfaction is comp...Continue Reading

References

Jun 1, 1977·Annals of Neurology·E C DoolingF H Gilles
Nov 1, 1978·Neurology·C M Fisher
Jul 1, 1992·Journal of Neurology·T P MeloF Regli
Nov 1, 1991·The Journal of Physiology·J G ColebatchA Guz
Feb 22, 1974·Brain Research·F Motokizawa
May 1, 1994·Neurology·D H SolomonJ Grissom
Jul 1, 1996·Neuroscience Research·N YatimC Buisseret-Delmas
Dec 1, 1996·Stroke; a Journal of Cerebral Circulation·M RousseauxM Romon
Sep 1, 1997·Radiology·D M YousemR L Doty
Jan 1, 1997·International Review of Neurobiology·J M Bower
Mar 17, 2000·Brain Research. Brain Research Reviews·F A Middleton, P L Strick
Sep 9, 2000·Journal of Neurophysiology·A QureshyH Fukuda
Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Paul KrackJerry Vitek
Apr 25, 2003·Journal of Neurophysiology·Bradley N JohnsonNoam Sobel
Sep 25, 2003·Surgical and Radiologic Anatomy : SRA·A CossonGuy Monnier
Oct 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·T ConnellyR L Doty
Dec 16, 2003·Journal of Neurology·Michael AbeleUllrich Wüllner
Jan 22, 2005·Brain : a Journal of Neurology·Jürgen KonczakDagmar Timmann
Jul 8, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joel D MainlandNoam Sobel
May 31, 2006·Advances in Oto-rhino-laryngology·Jay A Gottfried
Oct 6, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Thomas HummelA Mackay-Sim
Dec 13, 2006·Trends in Neurosciences·Leslie M Kay, S Murray Sherman
May 16, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jane PlaillyJay A Gottfried
Oct 6, 2009·Brain Research Reviews·Wendy W P ThamLaurie A Miller

Citations

Jan 28, 2014·PloS One·Hao JiaGopikrishna Deshpande
Dec 17, 2014·Journal of the Neurological Sciences·Paula M JanssenPeter J Koehler
Jun 7, 2018·PloS One·M KronenbuergerIrene Neuner
May 19, 2017·Nature Reviews. Neuroscience·Akiko SatohLeonard Guarente
Feb 9, 2012·Journal of the American Veterinary Medical Association·Vincent J GuerinAudrey F Petite
Jul 5, 2019·Chemical Senses·Albert Wabnegger, Anne Schienle
Feb 18, 2020·Journal of Neural Transmission·Thorsten HerrM Kronenbuerger
Oct 18, 2020·Brain Sciences·Thorsten HerrM Kronenbuerger

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.