Involvement of the Inflammasome and Th17 Cells in Skin Lesions of Human Cutaneous Leishmaniasis Caused by Leishmania (Viannia) panamensis.

Mediators of Inflammation
Kadir GonzálezMárcia Laurenti

Abstract

Localized cutaneous leishmaniasis (LCL) caused by Leishmania (Viannia) panamensis is an endemic disease in Panama. This condition causes ulcerated skin lesions characterized by a mixed Th1/Th2 immune response that is responsible for disease pathology. However, the maintenance of the in situ inflammatory process involves other elements, such as Th17 and inflammasome responses. Although these processes are associated with parasite elimination, their role in the increase in disease pathology cannot be discarded. Thus, the role in Leishmania infection is still unclear. In this sense, the present study aimed at characterizing the Th17 and inflammasome responses in the skin lesions of patients with LCL caused by L. (V.) panamensis to help elucidate the pathogenesis of this disease in Panama. Th17 and inflammasome responses were evaluated by immunohistochemistry (IHQ) in 46 skin biopsies from patients with LCL caused by L. (V.) panamensis. The Th17 immune response was assessed using CD3, CD4, RoRγt, IL-17, IL-6, IL-23, and TGF-β1 antibodies, and the inflammasome response was assessed by IL-1β, IL-18, and caspase-1 antibodies. The presence of the Th17 and inflammasome responses was evidenced by a positive reaction for all immunological...Continue Reading

References

Nov 1, 1986·Revista Do Instituto De Medicina Tropical De São Paulo·A V de MagalhãesP D Marsden
Oct 5, 1983·Journal of Medical Entomology·H A ChristensenA M de Vásquez
Nov 20, 2002·Infection and Immunity·Olívia BacellarEdgar M Carvalho
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
Aug 9, 2005·Immunology Letters·Lis R V AntonelliKenneth J Gollob
Jan 13, 2006·Nature·Thirumala-Devi KannegantiGabriel Núñez
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Euan LockhartJoAnne L Flynn
Aug 7, 2007·Nature Immunology·Nicholas J WilsonRene de Waal Malefyt
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Diego A Vargas-InchausteguiLynn Soong
Jun 20, 2008·Nature·Estelle BettelliVijay K Kuchroo
Jul 8, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Fernando T SilveiraCarlos E P Corbett
Jul 11, 2008·Immunological Reviews·Laura A TesmerDavid A Fox
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susanna Lopez KostkaEsther von Stebut
Mar 24, 2009·Annual Review of Immunology·Yasmine Belkaid, Kristin Tarbell
May 30, 2009·The Journal of Infectious Diseases·Olívia BacellarEdgar M Carvalho
Oct 10, 2009·The American Journal of Tropical Medicine and Hygiene·Aracelis MirandaJose E Calzada
Mar 17, 2010·Transactions of the Royal Society of Tropical Medicine and Hygiene·Ana Margarita Montalvo AlvarezCarlos Muskus
Mar 23, 2010·Cell·Kate Schroder, Jurg Tschopp
Sep 10, 2010·European Journal of Immunology·Tiago M CastilhoDiane McMahon-Pratt
Jul 24, 2012·Transactions of the Royal Society of Tropical Medicine and Hygiene·A MirandaJ E Calzada
Apr 23, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Diego M SantosCamila I de Oliveira
Jun 12, 2013·Nature Medicine·Djalma S Lima-JuniorDario S Zamboni
Dec 11, 2013·Frontiers in Cellular and Infection Microbiology·Larissa D Cunha, Dario S Zamboni
Feb 18, 2015·The Journal of Clinical Investigation·Prajwal GurungThirumala-Devi Kanneganti
Apr 17, 2015·Immunological Reviews·Dario S Zamboni, Djalma S Lima-Junior
Jun 30, 2015·Nature Medicine·Haitao GuoJenny P-Y Ting
Dec 17, 2017·The Journal of Investigative Dermatology·Daniela SantosLucas P Carvalho
Feb 17, 2018·Revista Do Instituto De Medicina Tropical De São Paulo·Kadir GonzálezAzael Saldaña
Jun 24, 2019·Current Opinion in Microbiology·Dario S Zamboni, David L Sacks

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
PCR
Assay
biopsy

Software Mentioned

AxioVision
OriginLab
Origin
GraphPad Prism

Related Concepts

Related Feeds

Related Papers

Frontiers in Microbiology
Amal O Amer
Current Biology : CB
Virginie PetrilliJürg Tschopp
Clinical Immunology : the Official Journal of the Clinical Immunology Society
Chunmei ZhaoJing Wang
Journal of Hepatology
Alexander Wree, Fabio Marra
© 2021 Meta ULC. All rights reserved