Involvement of the IRF family transcription factor IRF-3 in virus-induced activation of the IFN-beta gene

FEBS Letters
M SatoT Taniguchi

Abstract

The virus-induced activation of interferon alpha/beta (IFN-alpha/beta) gene transcription is essential for host defense. The IFN-beta promoter is controlled primarily by the virus-inducible enhancer elements, the IRF-Es. Here we show that IRF-3, an IRF family transcription factor, translocates to the nucleus from the cytoplasm upon virus infection in NIH/3T3 cells. The nuclear IRF-3 is phosphorylated, interacts with the co-activators CBP/p300, and binds specifically to the IFN-beta IRF-E. Furthermore, overexpression of IRF-3 causes a marked increase in virus-induced IFN-beta mRNA expression. Thus, IRF-3 is a candidate transcription factor mediating the activation of the IFN-beta gene.

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Citations

Dec 18, 2001·European Journal of Immunology·K SatoK Ogasawara
Jun 25, 2003·Biochemical and Biophysical Research Communications·Shinya SakaguchiTadatsugu Taniguchi
Aug 26, 2006·Nature Reviews. Immunology·Kenya Honda, Tadatsugu Taniguchi
Oct 7, 2008·Nature Structural & Molecular Biology·Weijun ChenWilliam E Royer
Apr 25, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·T IwamuraT Fujita
Mar 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Koon-Guan LeeKong-Peng Lam
Feb 21, 2002·The Journal of Experimental Medicine·Winfried BarchetUlrich Kalinke
Oct 30, 2003·Viral Immunology·Thais P Salazar-Mather, Kirsten L Hokeness
Dec 19, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M BehrC Jungwirth
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Betsy BarnesPaula M Pitha
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mitsutoshi YoneyamaTakashi Fujita
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Pierre MorinAhmet Civas
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·David E LevyArun Prakash
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Nancy C Reich
Feb 27, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J HiscottR Lin
Aug 28, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Beatriz Perdiguero, Mariano Esteban
Jan 5, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jing Jing KhooAshley Mansell
Mar 10, 2001·Cold Spring Harbor Symposia on Quantitative Biology·N MunshiD Thanos
Nov 12, 2010·Journal of Virology·Zhiguo SunJun Gu
Mar 22, 2002·Journal of Virology·Benjamin R tenOeverJohn Hiscott
Jul 29, 2004·Journal of Virology·Gregory T MelroeDavid M Knipe

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