PMID: 8585084Sep 1, 1995Paper

Involvement of the L-arginine-nitric oxide synthase pathway in the relaxant responses of the rat isolated anococcygeus muscle to a scorpion (Leiurus quinquestriatus quinquestriatus) venom

Toxicon : Official Journal of the International Society on Toxinology
M C GweeP Gopalakrishnakone

Abstract

Venom from several species of scorpions can cause generalized depolarization of peripheral nerves with enhancement of neurotransmitter release. The effects of the venom (LQV) from the scorpion Leiurus quinquestriatus quinquestriatus were investigated using the rat isolated carbachol (CCh) precontracted anococcygeus muscle (Acm) mounted in Krebs solution containing phentolamine (5 microM). LQV (0.2 microgram/ml and 1.5 micrograms/ml) markedly relaxed the tone of the CCh precontracted (non-stimulated) Acm by 31.5 +/- 5.1% and 35.5 +/- 4.7%, respectively; the onset was immediate after the high dose, followed by a slow and gradual return of the muscle tone to 88.7 +/- 1.8% of the initial peak tension in 50.2 +/- 4 min. Subsequent doses of LQV produced essentially no appreciable changes in muscle tone, but the addition of L-arginine (250 microM) or, especially sodium nitroprusside (SNP; 1 microM) produced marked and rapid relaxations of the Acm. Similar results were obtained with LQV during electrical field stimulation (EFS) of the precotracted Acm; however, during the gradual return of the muscle tone from the relaxed state induced by LQV, the EFS-induced relaxant (NANC) responses were also progressively inhibited by 84.9 +/- 3.4% ...Continue Reading

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Citations

Nov 10, 2000·Toxicon : Official Journal of the International Society on Toxinology·C E TeixeiraG De Nucci
Oct 8, 2003·Toxicon : Official Journal of the International Society on Toxinology·Cleber E TeixeiraEdson Antunes
Jun 24, 1998·Toxicon : Official Journal of the International Society on Toxinology·A J FataniI J Zeitlin
Dec 3, 2002·Journal of Pharmacological and Toxicological Methods·Li-Sam CheahSelvanayagam Nirthanan
Aug 8, 2002·Clinical and Experimental Pharmacology & Physiology·Matthew C E GweeLi-Sam Cheah
Mar 17, 1999·Journal of Toxicology. Clinical Toxicology·M BelghithF Abroug
Apr 16, 2013·Toxicon : Official Journal of the International Society on Toxinology·Kenia P NunesMaria E De Lima
May 29, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F BucaretchiE F Collares
Sep 6, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L E TronconJ R Cunha-Melo
Sep 5, 2003·Intensive Care Medicine·Fekri AbrougAlain Carayon

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