PMID: 6991914May 1, 1980Paper

Involvement of the L-cysteine biosynthetic pathway in azide-induced mutagenesis in Salmonella typhimurium

Mutation Research
Z CieślaT Kłopotowski

Abstract

L-Cystine and L-cysteine specifically reverse the mutagenic action of azide in Salmonella typhimurium and Escherichia coli. To establish whether the L-cysteine biosynthetic pathway is involved in azide-induced mutagenesis, several derivatives of a mutagen tester-strain of S. typhimurium bearing mutations in different cys genes were isolated. No mutagenic effect of azide was observed in a strain carrying mutation in the cysE gene, unless the incubation medium was supplemented with exogenous O-acetylserine. Our of 16 cysK mutants 14 were mutagenized by azide very poorly or not at all. These results indicate that the activity of O-acetylserine sulfhydrylase A, and the availability of O-acetylserine, one of the two co-substrates of the enzyme, are essential for the mutagenic action of azide in S. typhimurium.

References

Jul 1, 1979·Journal of General Microbiology·M FilutowiczT Kłopotowski
Sep 1, 1979·Mutation Research·M SzwackaT Kłopotowski
Mar 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J McCann, B N Ames
Oct 18, 1976·Molecular & General Genetics : MGG·M D Hulanicka, N M Kradich
Dec 1, 1976·Mutation Research·A Kleinhofs, J A Smith
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Feb 1, 1967·Virology·H O Smith, M Levine

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Citations

Nov 1, 1986·Chemico-biological Interactions·J B Mangold, J M Lavelle
Feb 1, 1988·Mutation Research·W M Owais, A Kleinhofs
Oct 16, 1994·Mutation Research·T H MaM F Salamone
Oct 16, 2016·ACS Chemical Biology·Kalie A MixRonald T Raines
May 11, 2010·Chembiochem : a European Journal of Chemical Biology·Marjoke F DebetsFloris L van Delft
Sep 1, 1983·Microbiological Reviews·K E Sanderson, J R Roth
Sep 1, 2008·EcoSal Plus·Nicholas M Kredich

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