Involvement of the mitochondrial ATP-sensitive potassium channel in the neuroprotective effect of hyperbaric oxygenation after cerebral ischemia

Brain Research Bulletin
Min LouGünther Deuschl

Abstract

In the present study, we investigated whether activation of mitochondrial ATP-sensitive potassium channel is involved in the neuroprotective effect offered by early hyperbaric oxygenation after cerebral ischemia. The selective mitochondrial ATP-sensitive potassium channel antagonist 5-hydroxydecanoate was infused intracerebroventricularly before hyperbaric oxygenation treatment initiated 3 h after middle cerebral artery occlusion for 90 min. Neurological status was evaluated and brains were removed for the measurement of infarct size and immunohistochemical evaluation of apoptosis 24 h after middle cerebral artery occlusion. Early hyperbaric oxygenation treatment improved neurologic deficits and reduced infarct volume, while these effects were reversed by the administration of 5-hydroxydecanoate. Furthermore, early hyperbaric oxygenation significantly decreased the number of apoptotic cells in the peri-infarct cortex 24 h after ischemic insult and this effect was also blocked by 5-hydroxydecanoate. The present findings suggest that early hyperbaric oxygenation therapy prevents apoptosis and promotes neurologic functional recovery after focal cerebral ischemia, and the opening of mitochondrial ATP-sensitive potassium channel pla...Continue Reading

References

Aug 15, 1997·The Biochemical Journal·G M Cohen
Nov 7, 2001·The Biochemical Journal·J NishiyamaZ Dong
Mar 29, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Dong LiuMark P Mattson
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Katsuyoshi ShimizuDavid W Busija
Apr 5, 2003·Stroke; a Journal of Cerebral Circulation·Jihong XuPeter Gohlke
Jul 5, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Dali YinJohn H Zhang
Jan 13, 2004·Stroke; a Journal of Cerebral Circulation·Min LouGünther Deuschl
Apr 3, 2004·Stroke; a Journal of Cerebral Circulation·Wolf-Ruediger SchäbitzStefan Schwab
Mar 22, 2005·Brain Research·Roland VeltkampStefan Schwab

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Citations

May 3, 2011·European Journal of Applied Physiology·Ray-Yau WangYea-Ru Yang
Oct 13, 2012·Translational Stroke Research·Robert P Ostrowski, John H Zhang
Jun 19, 2012·Medical Gas Research·Daniel A RossignolRichard E Frye
Dec 19, 2006·Current Opinion in Chemical Biology·Nidhi M Gangadhar, Brent R Stockwell
Mar 21, 2009·Neurological Research·Gerald A MatchettJohn H Zhang
Aug 8, 2013·Brain Research·Nihal Gunes CevikAkin Savas Toklu
Nov 9, 2016·Medical Gas Research·Qin HuJohn H Zhang
Apr 28, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L YangX Y Xiang
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Tao XiongDezhi Mu
Apr 7, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Chih-Sen KangTsung-Ming Lee
Sep 10, 2020·Biomolecules·Blaise CozeneCesar V Borlongan
Jan 28, 2020·Restorative Neurology and Neuroscience·Amir HadannyShai Efrati

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Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

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