Involvement of the neurokinin-2 receptor in airway smooth muscle stretch-activated contractions assessed in perfused intact bovine bronchial segments

The Journal of Pharmacology and Experimental Therapeutics
Jeremy M HernandezLuke J Janssen

Abstract

The airway response to deep inspirations (DIs) in asthmatics has been shown to be ineffective in producing bronchodilation and can even cause bronchoconstriction. However, the manner by which a DI is able to cause bronchoconstriction remains ambiguous. We sought to investigate the pathway involved in this stretch-activated contraction and whether this contraction is intrinsic to airway smooth muscle (ASM). In brief, intact bovine bronchial segments were dissected, and side branches were ligated and then mounted horizontally in an organ bath. Intraluminal pressure was measured under isovolumic conditions. Instantaneously opening and then closing the tap on a column of fluid 5 to 30 cm high evoked a sudden increase in intraluminal pressure (equivalent to the height of the column of fluid) followed by a stress relaxation response of the ASM. When tissues were stimulated with carbachol (10(-8) M) or serotonin (10(-7) M) for 10 min, and the consequent agonist-evoked pressure response was dissipated manually, the response to the same transmural stretch was accompanied by a slowly developing and prolonged increase in intraluminal pressure. This stretch-activated response was significantly diminished by the stretch-activated cation cha...Continue Reading

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Citations

Nov 3, 2012·Journal of Allergy·Peter B NobleHoward W Mitchell
Sep 15, 2011·Critical Care : the Official Journal of the Critical Care Forum·Christophe FaisyPhilippe Devillier
Oct 2, 2012·European Journal of Pharmacology·Jeremy Mark Hernandez, Luke Jeffrey Janssen
Jan 13, 2015·Canadian Journal of Physiology and Pharmacology·Jeremy Mark Hernandez, Luke Jeffrey Janssen
Jan 18, 2017·Cellular and Molecular Life Sciences : CMLS·Alexander WidiapradjaScott P Levick
Jul 20, 2011·The Journal of Pharmacology and Experimental Therapeutics·Jeremy Mark Hernandez, Luke Jeffrey Janssen
Sep 11, 2010·Journal of Applied Physiology·Peter B NobleLuke J Janssen
Apr 5, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hidemitsu KitamuraTakashi Nishimura
Nov 16, 2016·Respiratory Research·Morgan Le GuenChristophe Faisy

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