Involvement of the NO/cGMP/KATP pathway in the antinociceptive effect of the new pyrazole 5-(1-(3-fluorophenyl)-1H-pyrazol-4-yl)-2H-tetrazole (LQFM-021)

Nitric Oxide : Biology and Chemistry
Iziara F FlorentinoElson A Costa

Abstract

The pyrazol compounds are known to possess antipyretic, analgesic and anti-inflammatory activities. This study was conducted to investigate the peripheral antinociceptive effect of the pyrazole compound 5-(1-(3-Fluorophenyl)-1H-pyrazol-4-yl)-2H-tetrazole (LQFM-021) and involvement of opioid receptors and of the NO/cGMP/K(ATP) pathway. The oral treatments in mice with LQFM-021 (17, 75 or 300 mg/kg) decreased the number of writhing. In the formalin test, the treatments with LQFM-021 at doses of 15, 30 and 60 mg/kg reduced the licking time at both neurogenic and inflammatory phases of this test. The treatment of the animals with LQFM-021 (30 mg/kg) did not have antinociceptive effects in the tail-flick and hot plate tests. Furthermore, pre-treatment with naloxone (3 mg/kg i.p.), L-name (10 mg/kg i.p.), ODQ (10 mg/kg i.p.) or glibenclamide (3 mg/kg i.p.) antagonized the antinociceptive effect of LQFM-021 in both phases of the formalin test. In addition, it was also demonstrated that the treatments of mice with LQFM-021(15, 30 and 60 mg/kg) did not compromise the motor activity of the animals in the chimney test. Only the highest dose used in the antinociceptive study promoted changes in the open field test and pentobarbital-induced...Continue Reading

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Citations

Apr 16, 2016·Journal of Ethnopharmacology·Iziara F FlorentinoElson A Costa
May 23, 2016·Bioorganic & Medicinal Chemistry Letters·Paula L de Melo SouzaValéria de Oliveira
Jun 21, 2016·Journal of Ethnopharmacology·Evelyne da Silva BrumSara Marchesan Oliveira
Oct 30, 2016·European Journal of Pharmacology·Amanda F CidadeRicardo Menegatti
Aug 17, 2016·Chemical Biology & Drug Design·Lanussy Porfiro de OliveiraElson Alves Costa
Jul 26, 2017·The Biochemical Journal·Maria Fernanda Pessano FialhoSara Marchesan Oliveira
Jun 10, 2020·Canadian Journal of Physiology and Pharmacology·Mohammed MehannaAhmed El Mallah
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juan Rodríguez-SilverioJesús Arrieta
May 6, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Iziara F FlorentinoJan Tytgat
Sep 26, 2021·Behavioural Pharmacology·Samira MohammadiFatemeh Abbaszadeh
Nov 25, 2021·PloS One·Maria Alice Miranda Bezerra MedeirosJackson Roberto Guedes da Silva Almeida

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