Involvement of the nucleus accumbens-ventral pallidal pathway in postictal behavior induced by a hippocampal afterdischarge in rats

Brain Research
J MaL W Leung

Abstract

The hypothesis that postictal motor behaviors induced by a hippocampal afterdischarge (AD) are mediated by a pathway through the nucleus accumbens (NAC) and ventral pallidum (VP) was evaluated in freely moving rats. Tetanic stimulation of the hippocampal CA1 evoked an AD of 15-30 s and an increase in number of wet-dog shakes, face washes, rearings and locomotor activity. Bilateral injection of haloperidol (5 micrograms/side) or the selective dopamine D2 receptor antagonist, (+/-)-sulpiride (200 ng/side) before the hippocampal AD, into the NAC selectively reduced rearings and locomotor activity, but not the number of wet-dog shakes and face washes. Injection of R(+)-SCH-23390 (1 microgram/side), a D1 receptor antagonist, or rimcazole (0.4 mg/side), a sigma opioid receptor antagonist, into the NAC did not significantly alter postictal behaviors. Bilateral injection of muscimol (1 ng/side), a gamma-aminobutyric acid (GABAA) receptor agonist, into the VP before the AD significantly blocked all postictal behaviors. It is concluded that postictal locomotor activity induced by a hippocampal AD is mediated by activation of dopamine D2 receptors in the NAC and a pathway through the VP.

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Citations

Jan 13, 2004·Brain Research·Jingyi Ma, L Stan Leung
Aug 26, 1998·Biological Psychiatry·M Koch, U Ebert
Sep 7, 2000·Neuroscience and Biobehavioral Reviews·L S LeungR S McLachlan
Apr 17, 2003·Epilepsy & Behavior : E&B·L S Stewart, L S Leung
Oct 6, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jingyi Ma, L Stan Leung
Jun 13, 2002·Epilepsia·L Stan LeungRichard S McLachlan
Apr 9, 2005·Epilepsia·Lee S Stewart, L Stan Leung
Feb 23, 2013·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Ludmyla KandrataviciusJoão Pereira Leite
Aug 31, 2001·Biological Psychiatry·R A ChambersD W Self
Jul 26, 2000·Anesthesiology·K M TannerL S Leung
Apr 28, 2018·Brain Structure & Function·Suriya SubramanianDaniel S Zahm
Aug 3, 2017·Journal of Neural Transmission·J Vuong, Annaelle Devergnas

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