Involvement of the opioid system in the development and expression of sensitization to the locomotor-activating effect of ethanol

The International Journal of Neuropsychopharmacology
R CamariniH M Calil

Abstract

Previous studies have shown that pretreatment with naloxone (Nlx), an opiate antagonist, attenuates the stimulating effect of ethanol. The purpose of the present study was to determine the influence of Nlx on the development and expression of the sensitization to ethanol. Initially, effects of different doses of Nlx on the response to a low dose of ethanol (2.0 g/kg) were assessed. Nlx (1.0 and 3.0 mg/kg i.p.) decreased the stimulating effect of ethanol. Groups of mice were treated with saline or Nlx (1.0 mg/kg i.p.) plus saline or ethanol (2.0 g/kg i.p.) during 21 d. On day 25 of treatment all animals received an ethanol challenge (2.0 g/kg i.p.). It significantly increased the locomotor activity of mice that had received chronic ethanol (2.0 g/kg) once daily as compared to those that had received saline. Chronic administration of Nlx (1.0 mg/kg i.p.), during the same period of time, did not change the locomotor activity of the mice. However, the group concomitantly treated with Nlx+ethanol did not develop sensitization to the locomotor-activating effect of ethanol. Another experiment was carried out to determine the effects of Nlx on the expression of sensitization to ethanol. Acute pretreatment with Nlx did not change the re...Continue Reading

Citations

Jun 29, 2004·Behavioural Brain Research·Carla Sanchis-SeguraCarlos M G Aragon
Aug 17, 2010·Behavioural Brain Research·Ricardo Marcos PautassiNorman E Spear
Dec 9, 2009·Pharmacology, Biochemistry, and Behavior·Daniela F FukushiroRoberto Frussa-Filho
May 12, 2009·Neuroscience and Biobehavioral Reviews·Ricardo M PautassiNorman E Spear
Aug 26, 2006·Alcoholism, Clinical and Experimental Research·Christopher C LapishL Judson Chandler
Oct 22, 2011·Alcoholism, Clinical and Experimental Research·Raúl PastorCarlos M G Aragon
Oct 21, 2009·Developmental Psychobiology·Carlos AriasNorman E Spear
Apr 21, 2016·Brain Research Bulletin·Rosana Camarini, Ricardo Marcos Pautassi
Dec 28, 2010·Pharmacology, Biochemistry, and Behavior·Rosana CamariniHelena Maria Calil
Aug 23, 2011·The International Journal of Neuropsychopharmacology·Daniela F FukushiroRoberto Frussa-Filho
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Raúl Pastor, Carlos M G Aragon
Nov 24, 2016·Bulletin of Experimental Biology and Medicine·L G KolikS B Seredenin

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