Involvement of the orexin/hypocretin system in the pharmacological effects induced by Δ(9) -tetrahydrocannabinol

British Journal of Pharmacology
África FloresFernando Berrendero

Abstract

Anatomical, biochemical and pharmacological evidence suggest the existence of a crosstalk between the orexinergic and endocannabinoid systems. While the orexin receptor 1 (OX1 receptor) modulates the reinforcing properties of cannabinoids, the participation of orexins in the acute pharmacological effects of Δ(9) -tetrahydrocannabinol (THC) remains unexplored. We assessed the possible role of orexins in THC-induced hypolocomotion, hypothermia, antinociception, anxiolytic- and anxiogenic-like effects and memory impairment. Selective OX1 and OX2 receptor antagonists and OX1 knockout (KO) mice as well as prepro-orexin (PPO) KO mice were used as pharmacological and genetic approaches. CB1 receptor levels in control and PPO KO mice were evaluated by immunoblot analysis. The expression of c-Fos after THC treatment was analysed in several brain areas in wild-type mice and in mice lacking the PPO gene. The hypothermia, supraspinal antinociception and anxiolytic-like effects induced by THC were modulated by orexins through OX2 receptor signalling. OX1 receptors did not seem to be involved in these THC responses. No differences in CB1 receptor levels were found between wild-type and PPO KO mice. THC-induced increase in c-Fos expression wa...Continue Reading

References

Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·L de LeceaJ G Sutcliffe
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·J J HaganN Upton
Jul 25, 2000·Trends in Neurosciences·T S Kilduff, C Peyron
May 23, 2001·The Journal of Comparative Neurology·J N MarcusJ K Elmquist
Jan 30, 2002·British Journal of Pharmacology·Emmanuel ValjentRafael Maldonado
Feb 7, 2002·Regulatory Peptides·Miklós JászberényiGyula Telegdy
Aug 20, 2002·Psychopharmacology·Fernando Berrendero, Rafael Maldonado
Feb 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fernando BerrenderoRafael Maldonado
Mar 22, 2005·Psychopharmacology·Graciela N BalerioRafael Maldonado
Apr 7, 2006·Handbook of Experimental Pharmacology·K Mackie
May 9, 2007·Journal of Neurochemistry·Andrés OzaitaRafael Maldonado
Nov 29, 2007·Sleep·Rodrigo A EspañaThomas E Scammell
Dec 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sam A DeadwylerRobert E Hampson
May 17, 2008·Addiction Biology·Patricia RobledoRafael Maldonado
Aug 4, 2009·Nature Neuroscience·Emma PuighermanalAndrés Ozaita
Nov 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christelle AnacletJian-Sheng Lin
Nov 28, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pasqualina CastaldoSalvatore Amoroso
Feb 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ainhoa Plaza-ZabalaFernando Berrendero
Jul 8, 2010·The Journal of Gene Medicine·Carol KilkennyUNKNOWN NC3Rs Reporting Guidelines Working Group
Jul 17, 2010·The Journal of Physiology·UNKNOWN NC3Rs Reporting Guidelines Working Group
Jul 24, 2010·British Journal of Pharmacology·Carol KilkennyUNKNOWN NC3Rs Reporting Guidelines Working Group
Aug 7, 2010·Current Pharmaceutical Design·Lih-Chu ChiouShuu-Jiun Wang
Mar 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Enza PalazzoSabatino Maione
Jun 21, 2011·Biological Psychiatry·Arnau Busquets-GarciaAndrés Ozaita
Oct 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yu-Cheng HoLih-Chu Chiou
Mar 21, 2012·Molecular Neurobiology·Ainhoa Plaza-ZabalaFernando Berrendero
Aug 28, 2012·Pharmacology, Biochemistry, and Behavior·Nima Heidari-OranjaghiAbbas Haghparast
Mar 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Liya YangXinmin Simon Xie
May 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Luigia CristinoVincenzo Di Marzo
Jul 31, 2013·Biological Psychiatry·África FloresFernando Berrendero
Sep 6, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shingo SoyaTakeshi Sakurai
Nov 16, 2013·Nucleic Acids Research·Adam J PawsonUNKNOWN NC-IUPHAR
Nov 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Robert M SearsJoseph E Ledoux

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Citations

Sep 15, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christina M RuizStephen V Mahler

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