Involvement of the P1 cistron in overcoming eIF4E-mediated recessive resistance against Clover yellow vein virus in pea

Molecular Plant-microbe Interactions : MPMI
Kenji NakaharaIchiro Uyeda

Abstract

Two recessive genes (cyv1 and cyv2) are known to confer resistance against Clover yellow vein virus (ClYVV) in pea. cyv2 has recently been revealed to encode eukaryotic translation initiation factor 4E (eIF4E) and is the same allele as sbm1 and wlm against other potyviruses. Although mechanical inoculation with crude sap is rarely able to cause infection of a cyv2 pea, biolistic inoculation of the infectious ClYVV cDNA clone does. At the infection foci, the breaking virus frequently emerges, resulting in systemic infection. Here, a derived cleaved-amplified polymorphic sequence analysis showed that the breakings were associated with a single nonsynonymous mutation on the ClYVV genome, corresponding to an amino-acid substitution at position 24 (isoleucine to valine) on the P1 cistron. ClYVV with the point mutation was able to break the resistance. This is a first report demonstrating that P1 is involved in eIF4E-mediated recessive resistance.

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Citations

Jun 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kenji S NakaharaIchiro Uyeda
Jun 12, 2013·Molecular Plant-microbe Interactions : MPMI·Alberto CarbonellCarmen Simón-Mateo
Jan 11, 2014·Molecular Plant-microbe Interactions : MPMI·M SorelS German-Retana
Jul 9, 2014·Annual Review of Phytopathology·Chris C N van Schie, Frank L W Takken
Dec 4, 2014·Molecular Plant Pathology·Cèlia Guiu-AragonésAna Montserrat Martín-Hernández
Dec 7, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·B MouryC Caranta
Apr 12, 2014·Frontiers in Plant Science·Kristiina Mäkinen, Anders Hafrén
Jan 26, 2016·Molecular Plant Pathology·Jeyabharathy ChandrasekaranAmit Gal-On
Jun 27, 2015·Viruses·Hélène Sanfaçon
May 1, 2021·Microorganisms·Sandra Martínez-TuriñoJuan Antonio García
Apr 24, 2021·Annual Review of Phytopathology·Xiuling YangAiming Wang

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