Involvement of the p38 MAPK signaling cascade in stress response of RAW 264.7 macrophages

Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
E G NovoselovaE E Fesenko

Abstract

The role of the p38 MAPK signaling cascade was studied in stress response of RAW 264.7 macrophages to extremely low-intensity centimeter microwaves. Irradiation stimulated production of a number of cytokines (IL-1, IL-6, TNF-α, INF-γ and IL-10), as well as induced activation of the signaling cascades NF- κB and p38 MAPK, and enhanced expression of Hsp72 heat shock protein. In the presence of the cascade p38 MAPK inhibitor (p38 MAP kinase inhibitor XI), the stimulating effects of electromagnetic waves were abrogated either completely (for NF-κB and Hsp72) or partially (for p38 MAPK and cytokines). The results obtained are indicative of a high sensitivity of the signaling cascade p38 MAPK to the effect of low-intensity physical fields.

References

Mar 18, 2005·Annual Review of Immunology·P R TaylorS Gordon
Jul 12, 2005·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·E G NovoselovaE E Fesenko
Oct 28, 2009·Nature Reviews. Immunology·Ruslan Medzhitov, Tiffany Horng
Dec 19, 2013·Genes & Cancer·Anupama Munshi, Rajagopal Ramesh
Dec 17, 2014·International Journal of Radiation Biology·Olga V GlushkovaElena G Novoselova
Oct 5, 2016·Cold Spring Harbor Perspectives in Biology·Gökhan S Hotamisligil, Roger J Davis

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