Involvement of the paraventricular nucleus in the occurrence of arrhythmias in middle cerebral artery occlusion rats

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Shuwei JiaLing Wang

Abstract

Ischemic stroke complicating with arrhythmia is one of the main causes of sudden death. To investigate the association between ischemic stroke-induced arrhythmia and the activity of paraventricular nucleus (PVN), we used Fos protein as an objective indicator to illustrate the functional state of PVN neurons in middle cerebral artery occlusion (MCAO) rats, in single intracerebroventricular injection of l-glutamate rats and in application of MK-801 before l-glutamate injection and MCAO rats. The standard limb II electrocardiography was continuously recorded by a biological signal collecting and processing system. The experimental cerebral ischemic animal model was established by occluding the right middle cerebral artery. The Fos protein expression was detected by immunohistochemistry and Western blot. The incidence of arrhythmia was significantly higher than that of controls (75.89% versus 0%), and Fos protein expression in the PVN also increased significantly in MCAO rats; both of them could be blocked by prior application of MK-801. Intracerebroventricular injection of l-glutamate induced changes in Fos protein expression and arrhythmia similar to that in the stroke, which could also be blocked by prior application of MK-801. ...Continue Reading

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Citations

Apr 14, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Shu-Wei JiaYu-Feng Wang
Aug 5, 2017·Circulation Research·Zhili ChenJieli Chen
Oct 21, 2017·European Journal of Preventive Cardiology·Nina Japundžić-ŽigonDavid Murphy
Jul 9, 2020·Journal of Stroke·Maria H H BalchYousef Hannawi
Aug 15, 2018·Medizinische Klinik, Intensivmedizin und Notfallmedizin·E EgererF Erbguth
Dec 8, 2020·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Mine KöktürkMehmet Salih Nas
Dec 5, 2018·Lancet Neurology·Jan F ScheitzMatthias Endres

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