Involvement of the renal natriuretic peptide urodilatin in body fluid regulation

Seminars in Nephrology
C Drummer

Abstract

Urodilatin, a 32-aminoacid peptide, is expressed in distal tubular cells of the human kidney and presumably released into the luminal part of the nephron to exert its effect via activation of membrane-bound guanylyl cyclases (type A) at the medullary collecting duct. Thereby, the tubular reabsorption of sodium is inhibited and natriuresis is stimulated. The peptide is derived from the same gene and propeptide as the atrial natriuretic peptide (ANP), a more N-terminal cleavage in the human kidney than in other body tissues may be responsible for the existence of this renal natriuretic peptide and its increased stability in the extreme environment of the kidney and primary urine. The results of a sequence of human and animal physiology experiments has suggested that the renal natriuretic peptide, rather than its cardiac analog ANP, may play an essential role in mediating urinary sodium excretion. First observations are made suggesting a contribution of the renal natriuretic peptide also to disturbed sodium handling under pathophysiological conditions.

Citations

Sep 5, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C DrummerM Heer
Mar 15, 2006·Early Human Development·Rosa ManganaroMarina Gemelli
May 11, 2016·Forensic Science International : Synergy·Sayaka NagasawaHirotaro Iwase
Sep 5, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J RegnardP Norsk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
M HertenC Drummer
The Clinical Investigator
C DrummerR Gerzer
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
N J ChristensenP Norsk
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
M HeerC Drummer
© 2021 Meta ULC. All rights reserved