Involvement of the sarcoplasmic reticulum calcium pump in myocardial contractile dysfunction: comparison between chronic pressure-overload and stunning

Cardiovascular Drugs and Therapy
H S SharmaJ M Lamers

Abstract

Acute as well as chronic forms of heart failure involve mechanical dysfunction during systole and/or diastole. The rapid Ca2+ release from and Ca2+ reuptake into the tubuli of the sarcoplasmic reticulum are processes that critically determine normal systolic and diastolic myocardial function, which explains why in the last fifteen years so much attention has been paid to understand the performance of the sarcoplasmic reticulum Ca2+ pump during myocardial contractile dysfunction. In this communication we have reviewed the literature data on sarcoplasmic reticulum Ca2+ pump function in the chronically pressure-overloaded hypertrophied and stunned (post-ischemic reversibly injured) myocardium in the light of some new data from our laboratory. Results on the pressure-overloaded hypertrophied myocardium provide evidence that impaired relaxation is most likely due to a low capacity of the sarcoplasmic reticulum to pump Ca2+, a consequence of a lower density of Ca(2+)-pumping sites within the sarcotubular membranes. Contractile dysfunction in stunned myocardium is accompanied by an upregulation of the sarcoplasmic reticulum Ca2+ ATPase gene resulting in a slight increase of the Ca2+ pumping activity. The latter increase is likely an a...Continue Reading

References

Jan 1, 1997·Mediators of Inflammation·H S Sharma, D K Das
Mar 27, 1995·Annals of the New York Academy of Sciences·H A Van HeugtenJ M Lamers
Jan 20, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Randa Hilal-DandanWolfgang H Dillmann
Aug 1, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·H SchadN Mendler
Jun 29, 2000·Journal of Hypertension·N S DhallaT Netticadan

Citations

Dec 4, 1975·The New England Journal of Medicine·A M Katz
Mar 1, 1978·Journal of Molecular and Cellular Cardiology·J M LamersW C Hülsmann
Apr 1, 1978·Journal of Molecular and Cellular Cardiology·N S DhallaG P Sharma
Sep 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M D Stern, E G Lakatta
Oct 1, 1992·Journal of Molecular and Cellular Cardiology·E M DarlingG Meissner
Nov 1, 1992·Circulation Research·P KaplanW Flameng
Jan 1, 1992·Annual Review of Physiology·H Kusuoka, E Marban
Feb 1, 1992·Journal of Molecular and Cellular Cardiology·D M Yellon, D S Latchman
Oct 1, 1991·Cardiovascular Drugs and Therapy·W Schaper
Jan 1, 1991·The Journal of Clinical Investigation·A A KnowltonC S Apstein
May 1, 1990·The Journal of Clinical Investigation·M A MovsesianJ Krall
Sep 1, 1990·Circulation·R Bolli
Apr 1, 1990·Circulation Research·R J SchottW Schaper
Jan 11, 1990·The New England Journal of Medicine·A M Katz
Oct 1, 1989·Journal of Molecular and Cellular Cardiology·U LimbrunoM Mariani
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R NagaiM Periasamy
Jul 1, 1989·Journal of Molecular and Cellular Cardiology·B SchoutsenJ M Lamers
Mar 1, 1988·Journal of Molecular and Cellular Cardiology·N S DhallaD A Eyolfson
Mar 1, 1985·Journal of Molecular and Cellular Cardiology·E Carafoli
Aug 1, 1986·Journal of Molecular and Cellular Cardiology·S T RapundaloJ J Feher
Apr 1, 1987·Japanese Circulation Journal·N KonnoT Katagiri
Mar 1, 1973·The American Journal of Physiology·L A SordahlA Schwartz
Sep 20, 1973·The American Journal of Cardiology·A SchwartzL E Wyborny
Jan 1, 1982·Annual Review of Physiology·M Tada, A M Katz
Jun 17, 1994·Annals of the New York Academy of Sciences·H S SharmaW Schaper
Aug 1, 1993·Cardiovascular Research·J AndresW Schaper

Related Concepts

Myocardial Contraction
Ca(2+)-Transporting ATPase
Jaundice, Obstructive
Tissue Membrane
Cardiac Hypertrophy
Hypertrophy
Myocardium
Reuptake
Gene Expression Regulation, Enzymologic
Hibernation, Myocardial

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