Involvement of the serotonergic system of the ventral hippocampus (CA3) on amnesia induced by ACPA in mice

Behavioural Brain Research
Mohammad NasehiMohammad-Reza Zarrindast

Abstract

Interactions between the cannabinoid and serotonin systems have been reported in many studies. In the present study, we investigated the influence of the serotonergic receptor agents on amnesia induced by the cannabinoid CB1 receptor agonist, arachydonilcyclopropylamide (ACPA). Bilateral guide-cannulae were implanted to allow intra-CA3 microinjection of the drugs. The results showed that the intra-peritoneal (i.p.) injection of ACPA induce amnesia but did not alter head dip latency, head dip counts, and locomotion. Moreover, intra-CA3 injection of M-Chlorophenylbiguanide (M-CHL, a 5-HT3 serotonin receptor agonist), Y-25130 (a 5-HT3 serotonin receptor antagonist), RS67333 (a 5-HT4 serotonin receptor agonist), and RS23597-190 (a 5-HT4 serotonin receptor antagonist) impaired memory but have no effect on head dip latency and locomotor activity. In addition, intra-CA3 injection of Y-25130, RS67333, and RS23597-190 heighten the ACPA-induced amnesia and head dip counts while did not alter head dip latency and locomotor activity. On the other hand, intra-CA3 microinjection of M-CHL could not modify the ACPA-induced amnesia, head dip latency and locomotor activity whereas increased head dip counts. It can be concluded that the amnesia i...Continue Reading

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Citations

Jan 29, 2016·Brain Research·Mohammad NasehiMohammad-Reza Zarrindast
Oct 28, 2016·Behavioural Brain Research·Mohammad NasehiMohammad-Reza Zarrindast
Jun 15, 2016·Journal of Psychopharmacology·Mohammad NasehiMohammad-Reza Zarrindast
Nov 11, 2020·Neuroscience and Biobehavioral Reviews·Salar VaseghiMohammad-Reza Zarrindast
Dec 12, 2017·Brain Research Bulletin·Mohammad NasehiMohammad-Reza Zarrindast

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