Involvement of the spleen in murine B cell differentiation

European Journal of Immunology
Y RonS Segal

Abstract

Experiments were performed to study the influence of neonatal and adult splenectomy on B cell differentiation in mice. Lymph node cells of both groups were found to contain a significantly higher proportion of Ig-bearing cells. Moreover, these cells expressed a higher density of membrane Ig and a higher IgM/IgD ratio. In addition, the response of these cells to different polyclonal B cell activators, especially dextran sulfate, was much higher than the response of the sham-operated controls. Similar experiments were carried out in splenectomized and control animals that were lethally irradiated and reconstituted with different hemopoietic cell sources. The same pattern of results was obtained, except when reconstituting the irradiated animals with fetal liver cells. These experiments, which were performed at long time intervals post splenectomy, show that in the absence of the spleen, there is an accumulation of less mature B cells in the periphery implying an active role of the spleen in at least certain differentiation steps of the B cell lineage.

References

May 13, 1976·The New England Journal of Medicine·R H BuckleyM S Platt
Jan 1, 1977·Immunological Reviews·E S Vitetta, J W Uhr
Jan 1, 1977·American Journal of Hematology·W Krivit
Jan 1, 1974·Scandinavian Journal of Immunology·G DorvalH Wigzell
Sep 15, 1974·Experientia·R J Turner
Dec 1, 1974·Transplantation Proceedings·F P StuartF W Fitch
Nov 1, 1972·The Journal of Infectious Diseases·L S LeungR H Drachman
May 1, 1966·The Journal of Experimental Medicine·H R ShinefieldD Kaye
Jul 11, 1973·Nature: New Biology·L Olsson, M H Claësson
Oct 15, 1972·Experientia·P Kanakambika, V Muthnukkaruppan
Jan 1, 1974·Scandinavian Journal of Immunology·E GronowiczG Möller
Mar 1, 1968·Transplantation·J F Ferrer
Jun 21, 1969·Nature·J R BattistoE Cabrerra
Mar 1, 1957·The Journal of Infectious Diseases·L R DRAPER, D H SUSSDORF

Citations

Dec 1, 1984·Immunobiology·R H GislerG Holländer
Jul 1, 1990·European Journal of Immunology·F G KroeseL A Herzenberg
May 15, 1988·International Journal of Cancer. Journal International Du Cancer·P De BaetselierH Verschueren

Related Concepts

Rp-8-Br-cGMP
B-Lymphocytes
Cell Density
Cell Differentiation Process
Clone Cells
Saviosol
Cyclic GMP
Lymph Nodes
Mice, Inbred C3H
Spleen

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