Involvement of the spleen in the control of the immunogenic and phagocytic function of thioglycollate-induced macrophages

European Journal of Immunology
Y RonS Segal

Abstract

The immunogenic capacity of thioglycollate-induced peritoneal macrophages of adult splenectomized animals was compared to that of macrophages of sham-operated controls. Macrophages from splenectomized animals were found to be impaired in their function as antigen-presenting cells, both in the education of virgin initiator T lymphocytes and in the stimulation of antigen-specific T memory cells. Macrophages from splenectomized animals were also severely impaired in their phagocytic capacity, as assessed in an opsonin-dependent bacterial phagocytosis assay. However, they were not impaired in their ability to pinocytose soluble keyhole limpet hemocyanin. These results indicate that the spleen may play a decisive role in controlling the differentiation of peritoneal macrophages.

References

Jan 28, 1978·Lancet·J L SullivanR J Wedgwood
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E TzehovalM Feldman
Jan 1, 1978·Immunological Reviews·J E Niederhuber
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E TzehovalM Feldman
Jan 1, 1977·American Journal of Hematology·W Krivit
Sep 15, 1974·Experientia·R J Turner
Dec 1, 1974·Transplantation Proceedings·F P StuartF W Fitch
Feb 1, 1970·Archives of Disease in Childhood·M J Schumacher
May 1, 1966·The Journal of Experimental Medicine·H R ShinefieldD Kaye
Oct 15, 1972·Experientia·P Kanakambika, V Muthnukkaruppan
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Mar 30, 1974·Cellular Immunology·S G Rice, M Fishman
Mar 1, 1968·Transplantation·J F Ferrer
Jun 21, 1969·Nature·J R BattistoE Cabrerra
Jan 1, 1980·Scandinavian Journal of Immunology·B VrayA D Strosberg
Mar 1, 1957·The Journal of Infectious Diseases·L R DRAPER, D H SUSSDORF

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Citations

Jan 1, 1982·Cancer Metastasis Reviews·E GorelikM Feldman
May 1, 1983·Mechanisms of Ageing and Development·H T Cheung, M J Nadakavukaren
Nov 4, 2004·The Journal of Surgical Research·Hanna BesslerMeir Djaldetti
May 15, 1988·International Journal of Cancer. Journal International Du Cancer·P De BaetselierH Verschueren

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