Involvement of the transcriptional factor E2F1 in the regulation of the rRNA promoter

Experimental Cell Research
Olivier AyraultPaule Seite

Abstract

p16INK4a-pRB-E2F and ARF-MDM2-p53 are two major tumor suppressor networks involved in cell proliferation control. The nucleolar ARF protein binds to MDM2 to activate the growth suppressive functions of p53, but can also exert its tumor suppressor activity independently of p53, through mechanisms involving other regulators: in that manner, p14ARF has been shown to inhibit the transcriptional activity of E2F1 in vitro, suggesting that the two pathways intersect with one another. More recently, ARF has been shown to inhibit ribosomal RNA processing, and to specifically interact with the rRNA promoter, suggesting a role in the regulation of both maturation and transcription processes. We show here that E2F1 can bind the rRNA promoter and modulate its activity through the interaction with two E2F1-binding sequences we have identified. The regulation of ribosome biogenesis appears as a major p53-independent process, which involves both ARF and E2F1 to control cell proliferation.

References

Jun 1, 1995·Journal of Cellular Biochemistry·K L King, J A Cidlowski
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·G XuW Krek
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·X Q QinP D Adams
Oct 1, 1993·Molecular and Cellular Biology·K HelinA Fattaey
Aug 1, 1997·Molecular and Cellular Biology·R VoitI Grummt
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·S GaubatzD M Livingston
Sep 23, 1998·Nature·S BatesK H Vousden
Apr 14, 1999·Cell Death and Differentiation·M M Kasten, A Giordano
Jul 27, 2000·Molecular and Cellular Biology·W Zhai, L Comai
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·F MartelliS R Grossman
Aug 4, 2001·Molecular and Cellular Biology·S CiarmatoriR J White
Nov 26, 2002·Molecular and Cellular Biology·Abhishek DattaPradip Raychaudhuri
Feb 8, 2003·Current Opinion in Genetics & Development·Scott W Lowe, Charles J Sherr
Mar 7, 2003·Molecular Cell·Masataka SugimotoCharles J Sherr
Aug 29, 2003·Oncogene·Etsu TashiroMasaya Imoto
Oct 29, 2004·The EMBO Journal·Wencheng ZhuJoseph R Nevins

❮ Previous
Next ❯

Citations

Dec 31, 2009·The Journal of Biological Chemistry·Jason C PaikWeei-Chin Lin
Apr 22, 2014·FEBS Letters·Lior GolombMoshe Oren
May 16, 2018·Cell Death & Disease·Amanda S CouttsNicholas B La Thangue
Feb 14, 2016·Journal of Cell Science·Shijiao HuangChuanmao Zhang
Mar 17, 2011·Oncotarget·Paula L Miliani de Marval, Yanping Zhang
Mar 10, 2019·Nature Communications·Thomas DaubonAndréas Bikfalvi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.