Involvement of transient receptor potential vanilloid 1 channel expression in orofacial cutaneous hypersensitivity following tooth pulp inflammation

Journal of Oral Science
Tetsuro WataseB Ogiso

Abstract

A study was conducted to evaluate the mechanisms underlying ectopic orofacial pain associated with tooth pulp inflammation in rats. We observed a significant decrease in the head withdrawal threshold (HWT) response to mechanical and heat stimuli applied to the ipsilateral facial skin upon application of complete Freund's adjuvant (CFA) to the upper first molar (M1TP) in comparison to application of vehicle. A large number of trigeminal ganglion (TG) neurons showed transient receptor potential vanilloid 1 (TRPV1) immunoreactivity (IR), and some of them were retrogradely labeled with fluorogold injected into the facial skin. A large number of cells showing IR for glial fibrillary acidic protein (GFAP) were observed in the 2nd compared to the 1st or 3rd branch regions of the TG, and TG cells innervating the facial skin were also surrounded by GFAP-IR cells. After administration of TRPV1 antagonist into the facial skin of M1TP CFA-treated rats, the decrease of HWTs in response to mechanical and heat stimulation of the facial skin was significantly reversed. The present findings suggest that the excitability of TG neurons is enhanced upon tooth pulp inflammation, leading to overexpression of TRPV1 in TG neurons innervating the facia...Continue Reading

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Citations

Feb 19, 2020·Scientific Reports·Heather Lynn RossiIshmail Abdus-Saboor
Jan 31, 2021·Molecular Neurobiology·Yuhui LuoYong Chen
Jan 12, 2021·Frontiers in Cellular Neuroscience·Takayoshi MasuokaTakaharu Ishibashi
Feb 26, 2021·Brain Research·Rachel Feldman-Goriachnik, Menachem Hanani
May 1, 2019·Journal of Endodontics·Matthias WidbillerAnibal Diogenes

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