PMID: 20120726Feb 4, 2010Paper

Involvement of trisynaptic hippocampal pathway in generation of neural representations of object-place associations (analytical review)

Zhurnal vyssheĭ nervnoĭ deiatelnosti imeni I P Pavlova
I G Sil'kis

Abstract

A review. Possible mechanisms for generation of neural representations of object-place associations (NROPA) are analyzed in different parts of a neural network which include the hippocampus and parahippocampal complex. Streams of spatial and non-spatial information arrive to the hippocampus from the parahippocampal complex consisting of perirhinal, postrhinal and entorhinal cortical areas. We assume that, due to the absence of connections between lateral and medial areas of the entorhinal cortex, object-place associations are mostly formed in the hippocampus, but can also be generated in the perirhinal cortex due to existence of input from the postrhinal cortex. As both information streams converge on neurons of the dentate fascia and field CA3, a trisynaptic pathway through the hippocampus can play the basic role in the NROPA generation. Since the spatial information arrives in the neocortex and, therefore, reaches the parahippocampal complex and hippocampus approximately by 20 ms earlier than the "non-spatial" stream, only spatial information is processed firstly in the dentate fascia and field CA3. Generation of NROPA in the dentate fascia starts later, due to returning excitation from field CA3c. In the dentate fascia, sign...Continue Reading

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