Abstract
The aim of the present study was to test the hypothesis that the TRPV4-NO-cGMP-PKG cascade is involved in the maintenance of thermal hyperalgesia following chronic compression of the dorsal root ganglion (DRG) (the procedure hereafter termed CCD) in rats. CCD rats showed thermal hyperalgesia and increased nitrite production. Intrathecal administration of ruthenium red (TRPV4 antagonist, 0.1-1 nmol), TRPV4 antisense ODN (TRPV4 AS, 40 microg, daily for 7 days), N(G)-L-nitro-arginine methyl ester (l-NAME, inhibitor of NO synthase, 30-300 nmol), 1H-[1,2,4]-oxadiazolo [4,3-a] quinoxalin-1-one (ODQ, a soluble guanylate cyclase inhibitor, 50-100 nmol) or 8-(4-Chlorophenylthio) guanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer sodium salt (Rp-8-pCPT-cGMPS, a PKG inhibitor, 25-50 nmol) induced a significant (P<0.001) and dose-dependent increase in the paw withdrawal latency (PWL) compared with control rats, respectively. Ruthenium red (1 nmol), TRPV4 AS (40 microg, daily for 7 days) or L-NAME (300 nmol) decreased nitrite (an index of nitric oxide formation) in the DRG of CCD rats. In addition, the phorbol ester 4alpha-phorbol 12,13-didecanoate (4alpha-PDD, TRPV4 synthetic activator, 1 nmol), co-administered with L-NAME (300 nmol), at...Continue Reading
References
Sep 1, 1992·Neuroscience·S T MellerT J Maves
Nov 3, 1988·Nature·A DumuisJ Bockaert
Nov 24, 1988·Nature·J GarthwaiteR Chess-Williams
Oct 5, 1986·Nature·D Paupardin-TritschP Greengard
Jun 16, 1988·Nature·R M PalmerS Moncada
Aug 1, 1993·Pain·T OhkuboH Takahashi
Oct 1, 1995·Naunyn-Schmiedeberg's Archives of Pharmacology·U Förstermann, H Kleinert
Jun 1, 1996·British Journal of Pharmacology·D SalveminiM G Currie
Aug 1, 1996·Neuroscience·M SalterJ Garthwaite
Jan 1, 1997·Life Sciences·N Miyasaka, Y Hirata
Oct 1, 1998·Pain·San-Jue Hu, Jun-Ling Xing
Dec 22, 1999·Journal of Neurophysiology·X J SongR H LaMotte
Feb 5, 2000·Neuroscience·Y X TaoR A Johns
May 9, 2000·Biochemical Pharmacology·B P BoothH Fung
Nov 18, 2000·Cell·W LiedtkeS Heller
Jul 28, 2001·Anesthesia and Analgesia·J M ZhangS J Brull
Aug 8, 2001·Brain Research Bulletin·B H Bie, Z Q Zhao
Oct 19, 2001·Anesthesiology·S R ChenH L Pan
Feb 1, 2003·Brain Research·Norifumi YoneharaYoshinori Kamisaki
Feb 5, 2003·Journal of Vascular Research·Thomas StreckerKarl Messlinger
Mar 4, 2003·Journal of Neurophysiology·Xue-Jun SongZheng-Nan Wong
Apr 15, 2003·The Journal of Biological Chemistry·Makoto SuzukiMasashi Imai
Apr 25, 2003·British Journal of Pharmacology·Gustavo G VivancosSérgio H Ferreira
Apr 26, 2003·The European Journal of Neuroscience·Tamaki MabuchiSeiji Ito
May 17, 2003·The Journal of Pharmacology and Experimental Therapeutics·Gino VillettiMario Barbieri
Jul 19, 2003·Molecular Pharmacology·Chiung-Chun HuangKuei-Sen Hsu
Jul 25, 2003·Nature·Hiroyuki WatanabeBernd Nilius
Aug 5, 2003·Neuron·Nicole Alessandri-HaberJon D Levine
Aug 21, 2003·Pain·Xue-Jun SongRobert H LaMotte
Oct 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Wolfgang Liedtke, Jeffrey M Friedman
May 7, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicole Alessandri-HaberJon D Levine
Jun 10, 2004·The Journal of Biological Chemistry·Hiroshi TodakaMakoto Suzuki
Sep 8, 2004·Neuroscience·F TaoR A Johns
May 24, 2005·Pflügers Archiv : European journal of physiology·Roger G O'Neil, Stefan Heller
Aug 27, 2005·Journal of Neurophysiology·Xue-Jun SongEdgar T Walters
Oct 11, 2005·Pain·Nicole Alessandri-HaberJon D Levine
Oct 12, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Mitsuo TanabeHideki Ono
Jan 21, 2006·Journal of Neurophysiology·Z Y TanR H LaMotte
Apr 4, 2006·British Journal of Pharmacology·Keiko TakasuMitsuo Tanabe
Apr 8, 2006·American Journal of Physiology. Cell Physiology·Bin-Xian ZhangMichael S Katz
Aug 11, 2006·The Journal of Biological Chemistry·Paula L SmithDavid E Clapham
Sep 1, 2006·Headache·Paul L DurhamRoger Cady
Nov 10, 2006·Hearing Research·Hiroko Takeda-NakazawaToshio Yamashita
Nov 25, 2006·The Journal of Physiology·Andrew D GrantNigel W Bunnett
Mar 14, 2007·Experimental Physiology·Charles W BourqueReza Sharif-Naeini
Aug 28, 2007·Hearing Research·Hiroko Takeda-NakazawaToshio Yamashita
Nov 13, 2007·Neuroscience·A SasakiY Kuraishi
Jan 22, 2008·Neuroscience Letters·Yang ZhangShou-Wei Yue
Feb 1, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicole Alessandri-HaberJon D Levine
Mar 28, 2008·Journal of Neurochemistry·James A Windelborn, Peter Lipton
Citations
Oct 12, 2012·Neuroscience Bulletin·Xiao-Yu LinJun-Ling Xing
Oct 31, 2012·Journal of Cardiovascular Pharmacology·Jessica A FilosaGeraldine Rath
Dec 22, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Wei-Hsin ChenYi-Wen Lin
Jun 28, 2012·Cellular Signalling·Jaesun ChunSang Sun Kang
Mar 2, 2011·Behavioural Brain Research·Chao WangShou-Wei Yue
Sep 4, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·J FichnaM A Storr
Oct 1, 2013·Neurological Research·Liping NingShouwei Yue
Mar 6, 2015·Acta Physiologica·R C L VizinM C Almeida
Jul 9, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·S Michael SinclairLori A Setton
Jan 13, 2015·Neuroscience Letters·Jie WangShou-Wei Yue
Sep 13, 2014·The Journal of Surgical Research·Yao LuGordon Tin Chun Wong
Jan 24, 2014·Antioxidants & Redox Signaling·Jana E LorenzAchim Schmidtko
Jun 5, 2015·PloS One·Jaung-Geng LinYi-Wen Lin
Aug 10, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Yu-Juan QuShou-Wei Yue
Dec 17, 2016·Pharmaceuticals·Michael J Caterina, Zixuan Pang
Nov 18, 2017·Assay and Drug Development Technologies·William G DarbyPeter McIntyre
Oct 14, 2017·Scientific Reports·David Arredondo ZamarripaStéphanie Thébault
Nov 14, 2018·Pain·Jonas PetersenAchim Schmidtko
Nov 13, 2012·Experimental & Molecular Medicine·Sang Sun KangJaesun Chun
Jun 3, 2016·Physiological Reviews·John P M WhiteIstvan Nagy
Apr 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Zhenyu WuChunyang Zhu
Aug 20, 2020·Journal of Molecular Neuroscience : MN·Shengjun WuWenping Zhang
Dec 29, 2017·Neuroscience Bulletin·Carlene MooreWolfgang B Liedtke
Mar 28, 2018·Molecular Neurobiology·Hemant KumarInbo Han
Jun 25, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Jessica A Filosa, Jennifer A Iddings
Jun 24, 2015·Integrative Cancer Therapies·Juyong WangLixing Lao
May 5, 2017·The Journal of Headache and Pain·Yuanyuan DingWeimin Chen
May 21, 2021·Neurochemical Research·Xiaohua FanLiping Ning
Jun 20, 2021·Pain·Silvia Squillace, Daniela Salvemini