PMID: 2099353Jan 1, 1990Paper

Involvement of type I hypersensitivity in rapid rejection of Trichinella spiralis from adult rats

International Archives of Allergy and Applied Immunology
S Zhang, G A Castro

Abstract

The role of type I hypersensitivity in the rapid rejection of Trichinella spiralis from actively and passively immunized rats was examined. Net intestinal fluid secretion, which occurs during the rejection of the parasites, was used to verify the expression of local anaphylaxis and was examined for its possible role in the rejection process. Worm establishment in the small intestine 30 min after intraduodenal inoculation was significantly reduced in rats that were passively immunized with immune serum containing anti-Trichinella IgE as compared with recipients of normal serum. Worm-induced fluid secretion in immune rats was completely inhibited by the combined action of indomethacin and diphenhydramine. However, worm rejection was not affected. L-651,392, a 5-lipoxygenase inhibitor, also failed to prevent rejection. Ketanserin (a serotonin S2 receptor antagonist) and MDL-72222 (a serotonin S3 receptor antagonist) together blunted the rapid rejection response and reduced fluid secretion. Furthermore, intra-arterial perfusion of serotonin into nonimmune rats caused fluid secretion and reduced worm establishment. In nonimmune rats prostaglandin E2, cholera toxin, and hypertonic Krebs-mannitol solution were used to evoke the same l...Continue Reading

Citations

Jan 1, 1993·Parasitology Research·M T SantamarinaF M Ubeira
Aug 5, 1995·Lancet·H L DuPont, G D Marshall
Dec 21, 2005·Surgery·Yael HarariFrank G Moody
May 10, 2001·The Journal of Allergy and Clinical Immunology·F D Finkelman, J F Urban

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