Involvement of vesicular trafficking system in membrane targeting of the progeny influenza virus genome

Microbes and Infection
Shuichi JoKyosuke Nagata

Abstract

The genome of influenza type A virus consists of single-stranded RNAs of negative polarity. Progeny viral RNA (vRNA) replicated in the nucleus is nuclear-exported, and finally transported to the budding site beneath the plasma membrane. However, the precise process of the membrane targeting of vRNA is unclear, although viral proteins and cytoskeleton are thought to play roles. Here, we have visualized the translocation process of progeny vRNA using fluorescence in situ hybridization method. Our results provide an evidence of the involvement of vesicular trafficking in membrane targeting of progeny vRNA independent of that of viral membrane proteins.

References

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Citations

Apr 29, 2011·Journal of Virology·Amie J EisfeldYoshihiro Kawaoka
Aug 3, 2012·Journal of Virology·Atsushi KawaguchiKyosuke Nagata
Oct 10, 2013·Viruses·Edward C Hutchinson, Ervin Fodor
Dec 30, 2014·Virology·Michiko KumakuraKyosuke Nagata
Feb 1, 2012·Cellular Microbiology·Dimiter DemirovStephan Ludwig
Jun 28, 2016·Viruses·Michael BreenLuis Martínez-Sobrido
Jul 28, 2016·The Journal of General Virology·Marie O PohlSilke Stertz
Jan 29, 2019·Frontiers in Cell and Developmental Biology·Maria João Amorim
Jan 23, 2020·Viruses·Caitlin Simpson, Yohei Yamauchi
Jan 18, 2020·Chemical Reviews·Shu-Lin LiuDai-Wen Pang

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