Involvement of xanthine oxidase and hypoxia-inducible factor 1 in Toll-like receptor 7/8-mediated activation of caspase 1 and interleukin-1β.

Cellular and Molecular Life Sciences : CMLS
Sally A NicholasVadim V Sumbayev

Abstract

Inflammatory reactions to ssRNA viruses are induced by the endosomal Toll-like receptors (TLRs) 7 and 8. TLR7/8-mediated inflammatory reaction results in activation of the Nalp3 inflammasome via an unknown mechanism. Here we report for the first time that TLR7/8 mediate activation of xanthine oxidase (XOD) in an HIF-1α-dependent manner. XOD produces uric acid and reactive oxygen species, which could activate Nalp3 and therefore induce activation of caspase 1, known to convert inactive pro-IL-1β into active IL-1β. Specific inhibition of the XOD activity attenuates TLR7/8-mediated activation of caspase 1 and IL-1β release. These results were obtained using human THP-1 myeloid macrophages. The findings were verified by conducting in vivo experiments on mice.

References

Jun 13, 2001·Biochemical and Biophysical Research Communications·C KirschR Klinger
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yun-Jin JungLen Neckers
Dec 25, 2003·The Journal of Physiology·Cristine E Berry, Joshua M Hare
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Jul 12, 2005·The Journal of Clinical Investigation·Kol A Zarember, Harry L Malech
Jan 13, 2006·Nature·Thirumala-Devi KannegantiGabriel Núñez
Nov 18, 2006·Nature Immunology·Jörg H FritzStephen E Girardin
May 1, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Maria KapiszewskaAnna Lankoff
Dec 29, 2007·The Journal of Pathology·L A M CarneiroL H Travassos
Feb 17, 2009·American Journal of Respiratory and Critical Care Medicine·Pamela GasseIsabelle Couillin
May 14, 2009·Vascular Health and Risk Management·Jacob George, Allan D Struthers
Sep 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jason W GriffithRichard Bucala

❮ Previous
Next ❯

Citations

Dec 5, 2012·Expert Opinion on Investigational Drugs·Thomas MeyerEggert Stockfleth
Oct 21, 2014·Antioxidants & Redox Signaling·Justine M AbaisPin-Lan Li
Jun 3, 2014·Biochimica Et Biophysica Acta·Maria Giulia BattelliLetizia Polito
May 23, 2018·International Journal of Immunopathology and Pharmacology·Maria Fátima de Paula RamosNestor Schor
Mar 8, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Orestes Foresto-NetoClarice Kazue Fujihara
Aug 23, 2019·Molecular Medicine Reports·Jun-Jun HuangYa-Chun Li
Jan 4, 2020·Free Radical Biology & Medicine·Lisa MullenPietro Ghezzi
Feb 10, 2021·Antioxidants & Redox Signaling·Santiago Cuevas, Pablo Pelegrín
Nov 2, 2019·Free Radical Biology & Medicine·Anne Negre-SalvayreRobert Salvayre
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Xiaoting ChenHaibing Chen
Jun 11, 2021·Stroke; a Journal of Cerebral Circulation·Morsaleh GanjiAmir Lerman
Aug 10, 2021·International Journal of Inflammation·Irandi Putra PratomoAryo Tedjo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.