Abstract
Zizimin2 (Ziz2), also known as dedicator of cytokinesis 11 (DOCK11), is a guanine nucleotide exchange factor that is predominantly expressed in lymphoid tissues. Recent findings demonstrated that Ziz2 is involved in the development of B cells, including germinal centre B cells and marginal zone B cells. However, limited information is currently available on the roles of Ziz2 in B-1 cells, a B-cell subset that resides in body cavities and contributes to protection against foreign pathogens in a T-cell-independent manner. We herein show that Ziz2 and its widely expressed isoform Ziz3 (also known as DOCK10) may be involved in defective production of anti-bacterial IgM by aged B-1a cells, a CD5+ subset of B-1 cells. Natural IgM against typical bacterial epitopes was defectively produced by peritoneal B-1a cells from aged mice. The down-regulation of Ziz2/3 in B-1a cells appeared to be responsible for this defective IgM production, as demonstrated by Ziz2/3 double-knockout mice. Mechanistically, lower levels of basal AKT phosphorylation did not allow for the differentiation of Ziz2/3-deficient B-1a cells into plasma cells. Defective production of anti-bacterial IgM was not fully rescued by immunization, resulting in slightly weaker ...Continue Reading
References
Mar 1, 1981·The Journal of Experimental Medicine·D E BrilesR Barletta
Oct 18, 2000·Nature·M MaruyamaK Rajewsky
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·John McLayJohn R Schreiber
Feb 1, 2003·The Lancet Infectious Diseases·Punam MangtaniAndrew J Hall
May 2, 2003·The New England Journal of Medicine·Lisa A JacksonUNKNOWN Vaccine Safety Datalink
Feb 16, 2005·FEBS Letters·Akihiko NishikimiMitsuo Maruyama
Jul 26, 2005·Immunity·Karen M HaasThomas F Tedder
Sep 7, 2006·The Journal of Experimental Medicine·David Savitsky, Kathryn Calame
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tobias SchmelzleJoan S Brugge
Aug 13, 2009·Blood·Fukun GuoYi Zheng
Aug 24, 2010·Thorax·T WelteD Nathwani
Oct 16, 2010·Nature Reviews. Immunology·Michael R Ehrenstein, Clare A Notley
Dec 15, 2010·Nature Reviews. Immunology·Nicole Baumgarth
Dec 19, 2012·Small GTPases·Nicholl K PakesRobin S B Williams
Apr 20, 2013·Nature Immunology·Jörg J Goronzy, Cornelia M Weyand
Aug 22, 2013·The Journal of Infectious Diseases·Karen M HaasRama D Yammani
Nov 10, 2013·The Journal of Clinical Investigation·Marieta CaganovaStefano Casola
May 2, 2014·Transactions of the Royal Society of Tropical Medicine and Hygiene·Leon PetoHeiman F L Wertheim
Oct 23, 2014·The New England Journal of Medicine·Daniel M Musher, Anna R Thorner
Dec 31, 2014·The Journal of Experimental Medicine·Marianne BurbageFacundo D Batista
Mar 3, 2015·Immunity & Ageing : I & a·Takenori MatsudaMitsuo Maruyama
Mar 19, 2015·The New England Journal of Medicine·Marc J M BontenDiederick E Grobbee
Jun 19, 2015·Clinical Microbiology Reviews·K Aaron GenoMoon H Nahm
Aug 19, 2015·Lancet·Elena PrinaAntoni Torres
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nichol E HolodickThomas L Rothstein
Citations
Mar 3, 2020·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Mitsuo MaruyamaAkinori Takaoka
Oct 21, 2018·Aging·Yuji MoritaMitsuo Maruyama
Apr 4, 2020·The Journal of Biological Chemistry·Kazuhiko NamekataTakayuki Harada
Mar 9, 2021·The Journal of Biological Chemistry·Andrew P ThompsonPaul E Brennan