Involvements of p38 MAPK and oxidative stress in the ozone-induced enhancement of AHR and pulmonary inflammation in an allergic asthma model

Respiratory Research
Aihua BaoSuqin Ben

Abstract

Exposure to ambient ozone (O3) increases the susceptivity to allergens and triggers exacerbations in patients with asthma. However, the detailed mechanisms of action for O3 to trigger asthma exacerbations are still unclear. An ovalbumin (OVA)-established asthmatic mouse model was selected to expose to filtered air (OVA-model) or 1.0 ppm O3 (OVA-O3 model) during the process of OVA challenge. Next, the possible involvements of p38 MAPK and oxidative stress in the ozone actions on the asthma exacerbations were investigated on the mice of OVA-O3 model by treating them with SB239063 (a p38 MAPK inhibitor), and/or the α-tocopherol (antioxidant). Biological measurements were conducted including airway hyperresponsiveness (AHR), airway resistance (Raw), lung compliance (CL), inflammation in the airway lumen and lung parenchyma, the phosphorylation of p38 MAPK and heat shock protein (HSP) 27 in the tracheal tissues, and the malondialdehyde (MDA) content and the glutathione peroxidase (GSH-Px) activity in lung tissues. In OVA-allergic mice, O3 exposure deteriorated airway hyperresponsiveness (AHR), airway resistance (Raw), lung compliance (CL) and pulmonary inflammation, accompanied by the increased oxidative stress in lung tissues and p...Continue Reading

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Citations

Sep 24, 2020·Cellular and Molecular Life Sciences : CMLS·Jing-Ru LiuYing-Yong Zhao
Jul 30, 2019·Frontiers in Immunology·Sharon MumbyIan M Adcock
Oct 19, 2020·The International Journal of Biochemistry & Cell Biology·Christopher D PascoeAndrew J Halayko
Jan 23, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Na SunHaidong Kan
Jun 4, 2021·Biological & Pharmaceutical Bulletin·Hirofumi OginoHitoshi Ueno
Aug 11, 2021·American Journal of Respiratory Cell and Molecular Biology·Pedro HernandezAngela Haczku

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Methods Mentioned

BETA
lavage
bronchoalveolar lavage
ELISA
PCR
MDA

Software Mentioned

MFLab
SPSS

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