Inward rectification and implications for cardiac excitability

Circulation Research
C G NicholsA N Lopatin

Abstract

Since the cloning of the first inwardly rectifying K+ channel in 1993, a family of related clones has been isolated, with many members being expressed in the heart. Exogenous expression of different clones has demonstrated that between them they encode channels with the essential functional properties of classic inward rectifier channels, ATP-sensitive K+ channels, and muscarinic receptor-activated inward rectifier channels. High-level expression of cloned channels has led to the discovery that classic strong inward, or anomalous, rectification is caused by very steeply voltage-dependent block of the channel by polyamines, with an additional contribution by Mg2+ ions. Knowledge of the primary structures of inward rectifying channels and the ability to mutate them have led to the determination of many of the structural requirements of inward rectification. The implications of these advances for basic understanding and pharmacological manipulation of cardiac excitability may be significant. For example, cellular concentrations of polyamines are altered under different conditions and can be manipulated pharmacologically. Simulations predict that changes in polyamine concentrations or changes in the relative proportions of each pol...Continue Reading

References

Sep 1, 1992·Progress in Neurobiology·Y KurachiT Nakajima
Jan 1, 1991·Annual Review of Physiology·H Matsuda
Apr 1, 1974·Journal of Molecular and Cellular Cardiology·C M CaldareraG Moruzzi
Jan 1, 1984·Annual Review of Biochemistry·C W Tabor, H Tabor
Dec 20, 1994·Neuroreport·K F Raab-GrahamC A Vandenberg
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·F PérierC A Vandenberg
Aug 11, 1994·Nature·M L AshfordJ P Adelman
Dec 1, 1993·Trends in Pharmacological Sciences·K G Chandy, G A Gutman
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·N DascalD Trollinger
Jan 1, 1996·Annual Review of Physiology·D M Barry, J M Nerbonne
Nov 14, 1980·Science·C Holden

❮ Previous
Next ❯

Citations

Mar 14, 2002·The Journal of Comparative Neurology·Gregor LaubeRüdiger W Veh
Sep 25, 2004·Journal of Cellular Physiology·Anthony Collins, Maureen Larson
Apr 26, 2008·Pflügers Archiv : European journal of physiology·Won Sun ParkYung E Earm
Nov 13, 2008·Pflügers Archiv : European journal of physiology·De-Yong ZhangGui-Rong Li
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Amit S Dhamoon, José Jalife
Mar 18, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gillian Edwards, Arthur H Weston
Jun 28, 2005·Journal of Molecular and Cellular Cardiology·Thomas P Flagg, Colin G Nichols
Apr 12, 2003·Journal of Molecular and Cellular Cardiology·Meredith McLerieAnatoli Lopatin
Jul 17, 1998·Trends in Pharmacological Sciences·P FerdinandyG F Baxter
Jan 1, 1997·Cellular Signalling·K Williams
Jul 18, 2002·International Journal of Andrology·Cynthia A Carnes, Spencer J Dech
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·S L ShyngC G Nichols
Nov 27, 2008·The Journal of Biological Chemistry·Shizhen WangDecha Enkvetchakul
Feb 7, 2007·Acta Physiologica·M J KilleenC L-H Huang
Jan 1, 1997·Annual Review of Physiology·C G Nichols, A N Lopatin
Feb 6, 2002·The Journal of Clinical Investigation·Irene L EnnisH Bradley Nuss
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Regina Preisig-MüllerJürgen Daut
Oct 21, 2000·Journal of Molecular and Cellular Cardiology·A N LopatinA E Pegg
Feb 22, 2001·Journal of Molecular and Cellular Cardiology·M NagashimaH Yabu
Mar 29, 2001·Journal of Molecular and Cellular Cardiology·A N Lopatin, C G Nichols
Jun 17, 2008·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Eun A KoWon Sun Park
Jun 20, 1998·The Journal of Physiology·J M CordeiroW R Giles
May 22, 1998·The Journal of Physiology·X W Niu, R W Meech
Sep 10, 2003·The Journal of Physiology·D EnkvetchakulC G Nichols
Jan 24, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Grzegorz R Juszczak, Artur H Swiergiel
Dec 23, 2006·Journal of Molecular and Cellular Cardiology·Robert Dumaine, Jonathan M Cordeiro
Oct 29, 2009·Human Mutation·Paula L HedleyMichael Christiansen
Feb 28, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Masato Tsuboi, Charles Antzelevitch
Apr 10, 2014·Free Radical Biology & Medicine·Kai-Chien YangSamuel C Dudley
Aug 7, 2010·Journal of the American College of Cardiology·Enrico M ZardiArun J Sanyal
Apr 13, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Przemysław B RadwańskiSteven Poelzing
Sep 17, 2013·Journal of Molecular and Cellular Cardiology·Jonathan M CordeiroCharles Antzelevitch
Mar 24, 2009·Journal of Molecular and Cellular Cardiology·Keiko IshiharaSatoshi Matsuoka
Jan 14, 2003·Biophysical Journal·Hassan Musa, Richard D Veenstra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.