Inward rectifier K(+) currents and Kir2.1 expression in renal afferent and efferent arterioles

Journal of the American Society of Nephrology : JASN
Lisa ChiltonR D Loutzenhiser

Abstract

The afferent and efferent arterioles regulate the inflow and outflow resistance of the glomerulus, acting in concert to control the glomerular capillary pressure and glomerular filtration rate. The myocytes of these two vessels are remarkably different, especially regarding electromechanical coupling. This study investigated the expression and function of inward rectifier K(+) channels in these two vessels using perfused hydronephrotic rat kidneys and arterioles and myocytes isolated from normal rat kidneys. In afferent arterioles pre-constricted with angiotensin II, elevating [K(+)](0) from 5 to 15 mmol/L induced hyperpolarization (-27 +/- 2 to 41 +/- 3 mV) and vasodilation (6.6 +/- 0.9 to 13.1 +/- 0.6 microm). This manipulation also attenuated angiotensin II-induced Ca(2+) signaling, an effect blocked by 100 micromol/LBa(2+). By contrast, elevating [K(+)](o) did not alter angiotensin II-induced Ca2(+) signaling or vasoconstriction in efferent arterioles, even though a significant hyperpolarization was observed (from -30 +/- 1 to 37 +/- 3 mV, P = 0.003). Both vessels expressed mRNA for Kir2.1 and exhibited anti-Kir2.1 antibody labeling.Patch-clamp measurements revealed prominent inwardly rectifying and Ba(2+)-sensitive current...Continue Reading

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Citations

Aug 30, 2011·Pflügers Archiv : European journal of physiology·Charlotte Mehlin SorensenMax Salomonsson
Jun 24, 2011·Cardiovascular Research·Lisa ChiltonRodger Loutzenhiser
Apr 12, 2011·Acta Physiologica·L MagnussonM Salomonsson
May 23, 2008·American Journal of Physiology. Renal Physiology·Carmen M Troncoso BrindeiroPamela K Carmines
Aug 26, 2010·Physiological Genomics·Steven A Fisher
Mar 12, 2016·Pflügers Archiv : European journal of physiology·Kasper Moller Boje RasmussenCharlotte Mehlin Sorensen
Mar 22, 2015·Mathematical Medicine and Biology : a Journal of the IMA·Ioannis Sgouralis, Anita T Layton
May 13, 2015·Acta Physiologica·M SalomonssonC M Sorensen
Jul 9, 2016·Biochemical and Biophysical Research Communications·Yong QiaoBoqian Zhu
Apr 4, 2017·Acta Physiologica·M SalomonssonC M Sorensen
Jan 11, 2008·American Journal of Physiology. Renal Physiology·Qingli ZhangThomas L Pallone
Apr 11, 2008·American Journal of Physiology. Renal Physiology·Kosuke TakeyaMichael P Walsh
Nov 5, 2013·American Journal of Physiology. Heart and Circulatory Physiology·John J RehoSteven A Fisher
Jan 28, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Mallikarjuna R PabbidiRichard J Roman
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Dec 16, 2011·American Journal of Physiology. Renal Physiology·Charlotte Mehlin SorensenMax Salomonsson
Dec 17, 2019·American Journal of Physiology. Renal Physiology·Anna D ManisOleg Palygin
Dec 7, 2017·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Maik GollaschRudolf Schubert

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