PMID: 7543944Apr 1, 1995Paper

Inwardly rectifying currents of saccular hair cells from the leopard frog

Journal of Neurophysiology
J R Holt, R A Eatock

Abstract

1. Inwardly rectifying currents were characterized in sensory hair cells isolated from the saccules of leopard frogs, using the whole cell configuration of the patch-clamp technique in voltage-clamp mode. 2. Two types of inwardly rectifying currents were distinguishable based on their ionic selectivity, activation and deactivation kinetics, voltage dependence, dependence on external K+ and sensitivity to divalent cations. 3. One inwardly rectifying current displayed K+ selectivity, rapid monoexponential activation (tau approximately 1 ms at -120 mV), steep voltage dependence, dependence of the activation voltage range on external K+ and block by external Ba2+. We refer to this current as IK1, consistent with the terminology used for a similar current in cardiac cells. In 5 mM external K+, IK1 activated negative to -60 mV, was half-activated at -86 mV and fully activated by -110 mV. 4. The other inwardly rectifying current was a mixed K+/Na+ current with slow sigmoidal activation (slow tau approximately 100 ms at -120 mV) and deactivation, shallow voltage dependence and no dependence of the activation curve on external K+ and which was blocked by external Cd2+. This current was called Ih because of its similarities to Ih of phot...Continue Reading

Citations

Jun 19, 1996·Annals of the New York Academy of Sciences·A Rüsch, R A Eatock
Sep 12, 2003·Journal of Neurophysiology·Luigi CatacuzzenoFabio Franciolini
Apr 13, 1999·The American Journal of Physiology·A J Ricci, M J Correia
Oct 20, 2004·Journal of the Association for Research in Otolaryngology : JARO·Weng Hoe WongRuth Anne Eatock
Nov 15, 2008·The Journal of Biological Chemistry·Neeliyath A RamakrishnanDennis G Drescher
Sep 5, 2009·The Journal of Comparative Neurology·Felix E SchweizerLarry F Hoffman
Jul 25, 2012·Journal of the Association for Research in Otolaryngology : JARO·Frances L MeredithKatherine J Rennie
Dec 5, 2017·Frontiers in Cellular Neuroscience·Xiaorong Xu ParksJoseph C Holt
Jun 20, 2018·Integrative and Comparative Biology·Duane R McPherson
Jun 19, 1996·Annals of the New York Academy of Sciences·M J CorreiaK J Rennie
May 30, 1998·Journal of Neurophysiology·J S OghalaiW E Brownell
Dec 6, 2002·Journal of Neurophysiology·Alan M BrichtaJay M Goldberg
Mar 23, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·John Carey, Nivee Amin
Apr 26, 2013·International Journal of Molecular Sciences·Tao ZhouWei-Jia Kong
Aug 8, 2020·Journal of the Association for Research in Otolaryngology : JARO·Christopher G ClinardErin G Piker
Feb 21, 1998·Journal of Neurophysiology·M S Smotherman, P M Narins
Oct 19, 2004·The Journal of Physiology·Luigi CatacuzzenoFabio Franciolini
Jun 18, 1999·Annals of the New York Academy of Sciences·J R HoltR A Eatock
Sep 22, 1998·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R A EatockM Saeki
Oct 12, 2001·Brain Research Bulletin·B Fritzsch, K W Beisel
Jul 7, 1999·Hearing Research·M S Smotherman, P M Narins

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