Iodide excess regulates its own efflux: a possible involvement of pendrin

American Journal of Physiology. Cell Physiology
Jamile Calil-SilveiraMaria Tereza Nunes

Abstract

Adequate iodide supply and metabolism are essential for thyroid hormones synthesis. In thyrocytes, iodide uptake is mediated by the sodium-iodide symporter, but several proteins appear to be involved in iodide efflux. Previous studies demonstrated that pendrin is able to mediate apical efflux of iodide in thyrocytes. Acute iodide excess transiently impairs thyroid hormone synthesis, a phenomenon known as the Wolff-Chaikoff effect. Although the escape from this inhibitory effect is not completely understood, it has been related to the inhibition of sodium-iodide symporter-mediated iodide uptake. However, the effects of iodide excess on iodide efflux have not been characterized. Herein, we investigated the consequences of iodide excess on pendrin abundance, subcellular localization, and iodide efflux in rat thyroid PCCl3 cells. Our results indicate that iodide excess increases pendrin abundance and plasma membrane insertion after 24 h of treatment. Moreover, iodide excess increases pendrin half-life. Finally, iodide exposure also increases iodide efflux from PCCl3 cells. In conclusion, these data suggest that pendrin may have an important role in mediating iodide efflux in thyrocytes, especially under conditions of iodide excess.

References

Sep 1, 1992·The American Journal of Physiology·P GolsteinR Beauwens
Apr 1, 1984·Endocrinology·S J WeissE F Grollman
Apr 7, 1999·Nature Genetics·D A ScottL P Karniski
Feb 22, 2001·European Journal of Endocrinology·P H EngL E Braverman
Jun 28, 2001·Physiological Reviews·P M Yen
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Akio YoshidaKoichi Suzuki
Aug 1, 1963·The Journal of Clinical Investigation·L E BRAVERMAN, S H INGBAR
May 25, 2004·Endocrinology·Akio YoshidaKoichi Suzuki
May 7, 2005·Thyroid : Official Journal of the American Thyroid Association·J Wolff
Aug 18, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Silvia DossenaMarkus Paulmichl
Oct 18, 2007·The Journal of Clinical Endocrinology and Metabolism·Fernando PalosJoaquin Lado-Abeal
May 7, 2008·Journal of Cellular Physiology·A MuscellaC Storelli
Aug 12, 2008·Trends in Endocrinology and Metabolism : TEM·Peter KoppJuan Carlos Solis-S
Jan 29, 2010·American Journal of Physiology. Cell Physiology·Caroline Serrano-NascimentoMaria Tereza Nunes
Feb 23, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Hans Bürgi
Jun 22, 2011·Thyroid Research·Tomoyuki IwataTsutomu Nakashima
Oct 12, 2011·The Journal of Physiology·Peying Fong
Oct 18, 2011·Molecular and Cellular Endocrinology·Caroline Serrano-NascimentoMaria Tereza Nunes
Nov 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Silvia DossenaMarkus Paulmichl
Nov 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Silvia DossenaMarkus Paulmichl
Dec 2, 2011·The New England Journal of Medicine·Pornpoj PramyothinLewis E Braverman
Dec 7, 2013·Endocrine Reviews·Carla PortulanoNancy Carrasco
Jan 18, 2014·The Journal of Clinical Endocrinology and Metabolism·Ana Luiza GalrãoIleana G S Rubio
Sep 10, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Carmela IoscoKerry J Rhoden
Oct 10, 2014·American Journal of Physiology. Cell Physiology·L TwyffelsV Kruys

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Citations

Sep 7, 2016·International Journal of Cardiology·Markus-Johann DechantJochen Grohmann
Aug 29, 2016·Molecular and Cellular Endocrinology·Luciano E RossichGuillermo J Juvenal
Feb 14, 2018·Endocrine-related Cancer·Antonio De la Vieja, Pilar Santisteban
May 8, 2019·Journal of Nutrition and Metabolism·Hernando Vargas-UricoecheaJulián Murillo-Palacios

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